CHO-Ph-PEG5-amine TFA manufacturers
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| | CHO-Ph-PEG5-amine TFA Basic information |
| Product Name: | CHO-Ph-PEG5-amine TFA | | Synonyms: | CHO-Ph-PEG5-amine TFA;CHO-Ph-CONH-PEG5-azide;N3-PEG5-Ph-Ald;N-(17-Azido-3,6,9,12,15-pentaoxaheptadecyl)-4-formylbenzamide | | CAS: | 2566404-73-5 | | MF: | C20H30N4O7 | | MW: | 438.48 | | EINECS: | | | Product Categories: | | | Mol File: | 2566404-73-5.mol |  |
| | CHO-Ph-PEG5-amine TFA Chemical Properties |
| | CHO-Ph-PEG5-amine TFA Usage And Synthesis |
| Uses | N3-PEG5-aldehyde is a cleavable 5 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. N3-PEG5-aldehyde is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | | IC 50 | Cleavable Linker | | References | [1] Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. DOI:10.1038/nrd.2016.268 |
| | CHO-Ph-PEG5-amine TFA Preparation Products And Raw materials |
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