7-[3-[[2-(3,5-dihydroxyphenyl)-2-hydroxyethyl]amino]propyl]-3,7-dihydro-1,3-dimethyl-1H-purine-2,6-dione monohydrochloride
| 中文名称 | 7-[3-[[2-(3,5-dihydroxyphenyl)-2-hydroxyethyl]amino]propyl]-3,7-dihydro-1,3-dimethyl-1H-purine-2,6-dione monohydrochloride |
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| 中文同义词 | 盐酸瑞普特罗 标准品;化合物 T28519;化合物 REPROTEROL HYDROCHLORIDE |
| 英文名称 | 7-[3-[[2-(3,5-dihydroxyphenyl)-2-hydroxyethyl]amino]propyl]-3,7-dihydro-1,3-dimethyl-1H-purine-2,6-dione monohydrochloride |
| 英文同义词 | 7-[3-[[2-(3,5-dihydroxyphenyl)-2-hydroxyethyl]amino]propyl]-3,7-dihydro-1,3-dimethyl-1H-purine-2,6-dione monohydrochloride;Reproterol hydrochloride;7-[3-[[2-(3,5-Dihydroxyphenyl)-2-hydroxyethyl]-amino]propyl]-3,7-dihydro-1,3-dimethyl-1H-purin-2,6-dionmonohydrochlorid;7-[3-[[2-(3,5-Dihydroxyphenyl)-2-hydroxyethyl]amino]propyl]-1,3-dimethyl-7H-purine-2,6(1H,3H)-dione·hydrochloride;W 2946M;W-2946M |
| CAS号 | 13055-82-8 |
| 分子式 | C18H24ClN5O5 |
| 分子量 | 425.86666 |
| EINECS号 | 2359423 |
| 相关类别 | |
| Mol文件 | 13055-82-8.mol |
| 结构式 | ![7-[3-[[2-(3,5-dihydroxyphenyl)-2-hydroxyethyl]amino]propyl]-3,7-dihydro-1,3-dimethyl-1H-purine-2,6-dione monohydrochloride 结构式](CAS/GIF/13055-82-8.gif) |
7-[3-[[2-(3,5-dihydroxyphenyl)-2-hydroxyethyl]amino]propyl]-3,7-dihydro-1,3-dimethyl-1H-purine-2,6-dione monohydrochloride 性质
| 熔点 | 249-250° |
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7-[3-[[2-(3,5-dihydroxyphenyl)-2-hydroxyethyl]amino]propyl]-3,7-dihydro-1,3-dimethyl-1H-purine-2,6-dione monohydrochloride 用途与合成方法
Reproterol hydrochloride 是 β2-肾上腺素受体激动剂和磷酸二酯酶抑制剂双重作用剂。Reproterol hydrochloride 在人单核细胞中刺激 cAMP 产生的效果比沙丁胺醇和非特罗更为有效，显示其在增强气道功能方面的潜力。此外，Reproterol 显著抑制 LTB4 的产生，表明其具有抗炎特性。Reproterol hydrochloride 可能在哮喘和 COPD 等呼吸疾病中具有抑制效力。
安全信息
| 毒性 | LD50 in mice (mg/kg): 148 i.v., >10,000 orally (Habersang) |
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