Cyclopenta[c][1]benzopyran-8-ol, 2,2-difluoro-1,2,3,3a,4,9b-hexahydro-4-(4-hydroxyphenyl)-, (3aS,4R,9bR)-

Request For Quotation
Cyclopenta[c][1]benzopyran-8-ol, 2,2-difluoro-1,2,3,3a,4,9b-hexahydro-4-(4-hydroxyphenyl)-, (3aS,4R,9bR)- Suppliers list
Company Name: BOC Sciences  
Tel: 16314854226; +8616314854226
Email: inquiry@bocsci.com
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Email: marketing@targetmol.cn
Cyclopenta[c][1]benzopyran-8-ol, 2,2-difluoro-1,2,3,3a,4,9b-hexahydro-4-(4-hydroxyphenyl)-, (3aS,4R,9bR)- Basic information
Product Name:Cyclopenta[c][1]benzopyran-8-ol, 2,2-difluoro-1,2,3,3a,4,9b-hexahydro-4-(4-hydroxyphenyl)-, (3aS,4R,9bR)-
Synonyms:Cyclopenta[c][1]benzopyran-8-ol, 2,2-difluoro-1,2,3,3a,4,9b-hexahydro-4-(4-hydroxyphenyl)-, (3aS,4R,9bR)-;Estrogen receptor modulator 6
CAS:787621-78-7
MF:C18H16F2O3
MW:318.31
EINECS:
Product Categories:
Mol File:787621-78-7.mol
Cyclopenta[c][1]benzopyran-8-ol, 2,2-difluoro-1,2,3,3a,4,9b-hexahydro-4-(4-hydroxyphenyl)-, (3aS,4R,9bR)- Structure
Cyclopenta[c][1]benzopyran-8-ol, 2,2-difluoro-1,2,3,3a,4,9b-hexahydro-4-(4-hydroxyphenyl)-, (3aS,4R,9bR)- Chemical Properties
Boiling point 487.1±45.0 °C(Predicted)
density 1.42±0.1 g/cm3(Predicted)
pka9.79±0.30(Predicted)
Safety Information
MSDS Information
Cyclopenta[c][1]benzopyran-8-ol, 2,2-difluoro-1,2,3,3a,4,9b-hexahydro-4-(4-hydroxyphenyl)-, (3aS,4R,9bR)- Usage And Synthesis
UsesEstrogen receptor modulator 6 (compound 3a) is a selective estrogen receptor (ER) β agonist (Ki=0.44 nM). Estrogen receptor modulator 6 displays 19-fold selectivity for ERβ over ERα(Ki=8.4 nM)[1].
IC 50ERβ: 0.44 nM (Ki); ERα: 8.4 nM (Ki)
References[1] Richardson TI, et al. Benzopyrans as selective estrogen receptor beta agonists (SERBAs). Part 5: Combined A- and C-ring structure-activity relationship studies. Bioorg Med Chem Lett. 2007;17(20):5563-5566. DOI:10.1016/j.bmcl.2007.08.009
Cyclopenta[c][1]benzopyran-8-ol, 2,2-difluoro-1,2,3,3a,4,9b-hexahydro-4-(4-hydroxyphenyl)-, (3aS,4R,9bR)- Preparation Products And Raw materials
Tag:Cyclopenta[c][1]benzopyran-8-ol, 2,2-difluoro-1,2,3,3a,4,9b-hexahydro-4-(4-hydroxyphenyl)-, (3aS,4R,9bR)-(787621-78-7) Related Product Information
27-Hydroxycholesterol Fulvestrant Estrone 3-sulfate sodium salt 4-Hydroxytamoxifen Ethinyl Estradiol β-Estradiol