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| | 1,2-dihydro-1,5-dimethyl-4-(methylamino)-2-phenyl-3H-pyrazol-3-one Basic information |
| | 1,2-dihydro-1,5-dimethyl-4-(methylamino)-2-phenyl-3H-pyrazol-3-one Chemical Properties |
| Melting point | 50-53°C | | Boiling point | 324.5±45.0 °C(Predicted) | | density | 1.20±0.1 g/cm3 (20 ºC 760 Torr) | | storage temp. | -20°C Freezer | | solubility | Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly) | | pka | 4.76±0.20(Predicted) | | form | Solid | | color | Pale Yellow to Brown |
| HazardClass | IRRITANT | | Toxicity | LD50 oral in mouse: 7gm/kg |
| | 1,2-dihydro-1,5-dimethyl-4-(methylamino)-2-phenyl-3H-pyrazol-3-one Usage And Synthesis |
| Chemical Properties | Pale Orange Low Melting Waxy Solid | | Uses | A metabolite of Dipyrone, a nonsteroidal anti-inflammatory drug. | | Definition | ChEBI: A member of the class of pyrazoles that is antipyrine substituted at C-4 by a methylamino group. It is a metabolite of aminopyrine and of metamizole. | | in vivo | The aim of this study is to assess the pharmacokinetics of its active metabolites 4-Methylamino antipyrine in male piglets after a single intramuscular injection of Metamizole. Eight healthy male piglets are administered Metamizole (100 mg/kg) intramuscularly. 4-Methylamino antipyrine plasma concentrations are quantitatively detectable from 0.25 to 48 h. The average maximum concentrations of 4-Methylamino antipyrine is of 47.59 mg/mL. The average half-lives is 8.57 h for 4-Methylamino antipyrine[1]. |
| | 1,2-dihydro-1,5-dimethyl-4-(methylamino)-2-phenyl-3H-pyrazol-3-one Preparation Products And Raw materials |
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