| Company Name: |
Maintain Biotech Co., Ltd. Gold
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| Tel: |
755-89664337 19125366885 |
| Email: |
sales@maintain-bio.com |
| Products Intro: |
Product Name:Nicotinamide Riboside Tartrate
CAS:2415657-86-0
Purity:99% HPLC Package:25kg/桶
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| Company Name: |
Shandong RuiYue Biotechnology Co., Ltd. Gold
|
| Tel: |
0531-88581623 18805314509 |
| Email: |
1456922171@126.com |
| Products Intro: |
Product Name:Nicotinamide riboside tartrate
CAS:2415657-86-0
Purity:99% Package:1kg;25kg
|
Nicotinamide riboside tartrate manufacturers
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| | Nicotinamide riboside tartrate Basic information |
| | Nicotinamide riboside tartrate Chemical Properties |
| InChIKey | TXLSDIXNZRLFCH-TUYXCLBSNA-N | | SMILES | O[C@@H]1[C@@H]([C@@H](CO)O[C@H]1[N+]1=CC=CC(C(=O)N)=C1)O.[C@H](O)(C(=O)[O-])[C@@H](O)C(=O)O |&1:1,2,3,7,18,23,r| |
| | Nicotinamide riboside tartrate Usage And Synthesis |
| Uses | Nicotinamide riboside tartrate, an orally active NAD+ precursor, increases NAD+ levels and activates SIRT1 and SIRT3. Nicotinamide riboside tartrate is a source of vitamin B3 (niacin) and enhances oxidative metabolism, protection against high fat diet-induced metabolic abnormalities[1]. Nicotinamide riboside tartrate reduces cognitive deterioration in a transgenic mouse model of Alzheimer’s disease[2]. | | in vivo | Chronic Nicotinamide riboside tartrate (p.o.; 400 mg/kg/day; for 16 weeks) supplementation increases plasma and intracellular NAD+ content in a tissue-specific manner[1]. | Animal Model: | 10-week-old C57Bl/6J mice[1] | | Dosage: | 400 mg/kg | | Administration: | PO; daily; for 16 weeks | | Result: | Increased plasma and intracellular NAD+ content in a tissue-specific manner.
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| | IC 50 | SIRT1; SIRT3; Human Endogenous Metabolite | | References | [1] Cantó C, et al. The NAD(+) precursor nicotinamide riboside enhances oxidative metabolism and protectsagainst high-fat diet-induced obesity. Cell Metab. 2012 Jun 6;15(6):838-47. DOI:10.1016/j.cmet.2012.04.022
[2] Bing Gong, et al. Nicotinamide Riboside Restores Cognition Through an Upregulation of Proliferator-Activated Receptor-γ Coactivator 1α Regulated β-Secretase 1 Degradation and Mitochondrial Gene Expression in Alzheimer's Mouse Models. Neurobiol Aging. 2013 Jun;34(6):1581-8. DOI:10.1016/j.neurobiolaging.2012.12.005
[3] Collin D Heer, et al. Coronavirus and PARP Expression Dysregulate the NAD Metabolome: A Potentially Actionable Component of Innate Immunity. bioRxiv. 2020 Apr 30;2020.04.17.047480. DOI:10.1101/2020.04.17.047480 |
| | Nicotinamide riboside tartrate Preparation Products And Raw materials |
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