|
|
| | 4-Chloro-2,6-dimethylpyridine Basic information |
| | 4-Chloro-2,6-dimethylpyridine Chemical Properties |
| Boiling point | 83-90 °C(Press: 40 Torr) | | density | 1.113±0.06 g/cm3(Predicted) | | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | form | liquid | | pka | 5.22±0.10(Predicted) | | color | Clear, colourless |
| Hazard Codes | Xi | | HS Code | 2933399990 |
| | 4-Chloro-2,6-dimethylpyridine Usage And Synthesis |
| Synthesis | (1) Synthesis of 4-chloro-2,6-dimethylpyridine: 2,6-dimethyl-4-hydroxypyridine (1 g) was dissolved in phosphoryl chloride (5 mL). The reaction mixture was stirred at 100 °C for 6 hours. Upon completion of the reaction, the reaction was quenched by the slow addition of water, followed by adjusting the pH to neutral with 5N aqueous sodium hydroxide and liquid-liquid extraction with ethyl acetate. The organic layers were combined, washed with saturated brine and then dried with anhydrous magnesium sulfate. The desiccant was removed by filtration and the filtrate was concentrated under reduced pressure to afford the target product 4-chloro-2,6-dimethylpyridine (1.15 g). The product was characterized by 1H-NMR (400 MHz, CDCl3): δ (ppm) 2.51 (s, 6H), 6.99 (s, 2H). | | References | [1] Bioorganic and Medicinal Chemistry, 2010, vol. 18, # 2, p. 630 - 639
[2] Patent: US2013/143907, 2013, A1. Location in patent: Paragraph 0485; 0486 |
| | 4-Chloro-2,6-dimethylpyridine Preparation Products And Raw materials |
|