- 2-Cyano-5-fluoropyridine
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- $1.10 / 1g
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2025-06-25
- CAS:327056-62-2
- Min. Order: 1g
- Purity: 99.0% min
- Supply Ability: 100 tons min
- 2-Cyano-5-fluoropyridine
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- $15.00 / 1KG
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2021-07-13
- CAS:327056-62-2
- Min. Order: 1KG
- Purity: 99%+ HPLC
- Supply Ability: Monthly supply of 1 ton
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| | 2-Cyano-5-fluoropyridine Basic information |
| | 2-Cyano-5-fluoropyridine Chemical Properties |
| Melting point | 35-41 °C | | Boiling point | 214.9±20.0 °C(Predicted) | | density | 1.24±0.1 g/cm3(Predicted) | | Fp | 99 °C | | storage temp. | Inert atmosphere,Room Temperature | | solubility | soluble in Methanol | | pka | -2.74±0.10(Predicted) | | form | powder to crystal | | color | White to Almost white | | InChI | InChI=1S/C6H3FN2/c7-5-1-2-6(3-8)9-4-5/h1-2,4H | | InChIKey | BHXHRMVSUUPOLX-UHFFFAOYSA-N | | SMILES | C1(C#N)=NC=C(F)C=C1 |
| Hazard Codes | Xn,N | | Risk Statements | 22-41-50/53 | | Safety Statements | 26-39-60-61 | | RIDADR | UN3439 | | WGK Germany | 3 | | HazardClass | 6.1 | | PackingGroup | III | | HS Code | 2933399990 | | Storage Class | 6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects | | Hazard Classifications | Acute Tox. 4 Oral
Aquatic Acute 1
Eye Dam. 1 |
| | 2-Cyano-5-fluoropyridine Usage And Synthesis |
| Uses | 5-Fluoro-2-pyridinecarbonitrile is a biochemical reagent that can be used as a biological material or organic compound for life science related research. | | Definition | ChEBI: 2-Cyano-5-fluoropyridine is a member of pyridines. | | Synthesis | General procedure for the synthesis of 2-cyano-5-fluoropyridine from 3-amino-6-cyanopyridine: Sodium nitrite (8.7 g, 126 mmol) was added in batches to ice-salt-bath-cooled 5-amino-pyridine-2-carbonitrile (10.03 g, 84.2 mmol) dissolved in a solution of 70% hydrogen fluoride-pyridine (Aldrich, 100 g, 3.5 mol HF) ( Note: the reaction was carried out in a special reaction flask). The reaction solution was dark red in color, and after stirring in an ice-salt bath for 45 min, the ice bath was removed and the mixture continued to be stirred at room temperature for 30 min, followed by heating at 80 °C for 1.5 h. The reaction was carried out in a special reaction flask. Upon completion of the reaction, the reaction mixture was quenched by slowly pouring it into an ice/water mixture (about 400 g), extracted with dichloromethane (6 x 150 mL), the organic phase was dried over anhydrous magnesium sulfate, filtered and the solvent was concentrated under reduced pressure. The resulting crude product (10.08 g, 98% yield, orange solid) was pure enough for subsequent use and did not require further purification. The product was characterized by 1H NMR (CDCl3, 300 MHz): δ= 8.61 (d, 1H), 7.78 (m, 1H), 7.58 (m, 1H).GC-MS showed the molecular ion peak M+ 122. | | References | [1] Patent: WO2005/66155, 2005, A1. Location in patent: Page/Page column 23
[2] Patent: EP1621537, 2006, A1. Location in patent: Page/Page column 57-58
[3] Patent: EP1640366, 2006, A1. Location in patent: Page/Page column 137-138
[4] Patent: EP1803719, 2007, A1. Location in patent: Page/Page column 27
[5] Patent: US2010/41717, 2010, A1. Location in patent: Page/Page column 41-42 |
| | 2-Cyano-5-fluoropyridine Preparation Products And Raw materials |
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