- L-BMAA HYDROCHLORIDE
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- $0.00 / 25kg
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2025-12-01
- CAS:16012-55-8
- Min. Order: 1kg
- Purity: 98%
- Supply Ability: 1000kg
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| | L-BMAA HYDROCHLORIDE Basic information |
| Product Name: | L-BMAA HYDROCHLORIDE | | Synonyms: | s(+)-2-amino-3-(methylamino)propionic acid hydrochloride;3-(Methylamino)-L-alanine monohydrochloride;L-2-aMino-3(MethylaMino)propanoic acid hydrochloride;L-BMAA.HCL;H-Dap(Me)-OH
(S)-2-Amino-3-(methylamino)propanoic acid hydrochloride;(S)-2-AMINO-3-(METHYLAMINO)PROPANOIC ACID HCL;β-Methylamino-L-alanine Hydrochloride;(2S)-2-amino-3-(methylamino)propanoic acid hydrochloride | | CAS: | 16012-55-8 | | MF: | C4H10N2O2HCl | | MW: | 0 | | EINECS: | | | Product Categories: | | | Mol File: | 16012-55-8.mol |  |
| | L-BMAA HYDROCHLORIDE Chemical Properties |
| Melting point | >147°C (dec.) | | storage temp. | -20°C | | solubility | H2O: soluble (solutions may be stored for several days at 4°C) | | form | powder | | color | white to beige | | Optical Rotation | [α]20/D +35°, c = 1.15 in 5 M HCl(lit.) | | Water Solubility | Soluble to 60 mM in water | | Stability: | Hygroscopic | | InChI | 1S/C4H10N2O2.ClH/c1-6-2-3(5)4(7)8;/h3,6H,2,5H2,1H3,(H,7,8);1H/t3-;/m0./s1 | | InChIKey | VDXYGASOGLSIDM-DFWYDOINSA-N | | SMILES | Cl.CNC[C@H](N)C(O)=O |
| Safety Statements | 22-24/25 | | WGK Germany | 3 | | HazardClass | IRRITANT | | Storage Class | 11 - Combustible Solids |
| | L-BMAA HYDROCHLORIDE Usage And Synthesis |
| Uses | L-BMAA hydrochloride has been used as a standard to compare all the samples in the analysis of β-N-methylamino-l-alanine (BMAA) isomers in desert crust material. It has also been used as an additive with f/2+Si mediumto treat the cells ofPhaeodactylum tricornutum andThalassiosira weissflogiito study its effect on them. | | General Description | L-BMAA hydrochloride/β-N-methylamino-l-alanine (BMAA) is a cyanobacterial neurotoxin. | | Biochem/physiol Actions | L-BMAA hydrochloride helps to block the addition of heparan sulfate to glypican-1. It possesses unusual glutamate receptor binding properties. It may cause amyotrophic lateral sclerosis/Lou Gehrig′s disease. | | in vivo | β-N-methylamino-L-alanine (460 mg/kg, s.c., daily, 2 weeks) hydrochloride inhibits melatonin synthesis in a Wistar rat model[4].
β-N-methylamino-L-alanine (BMAA-HCl, 400 mg kg, s.c.) hydrochloride induces developmental neurotoxicity in a rat model[5].
β-N-methylamino-L-alanine (100-350 mg/kg, i.p., 5 consecutive days) hydrochloride causes neurological and pathological phenotypes mimicking Amyotrophic Lateral Sclerosis (ALS) in male rats[6].
β-N-methylamino-L-alanine (5-10 nmol, intravitreal injections) hydrochloride induces in vivo retinal cell death in mice[8].
β-N-methylamino-L-alanine (250 mg/kg, i.p., 5 consecutive days) hydrochloride produces oxidative damage in liver and kidney of rats, with the significant increase of lipid peroxidation and high catalase activity[12].
β-N-methylamino-L-alanine (40-460 mg/kg, s.c., 2 days) hydrochloride perturbs the intermediary metabolism in neonatal rats, with impairments in learning and memory function[13].
| | IC 50 | mGluR3 | | storage | Store at -20°C |
| | L-BMAA HYDROCHLORIDE Preparation Products And Raw materials |
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