| Company Name: |
ChemeGen |
| Tel: |
18818260767 |
| Email: |
2625930290@qq.com |
28-Acetylbetulin manufacturers
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| | 28-Acetylbetulin Basic information |
| Product Name: | 28-Acetylbetulin | | Synonyms: | 28-Acetylbetulin;Lup-20(29)-ene-3,28-diol, 28-acetate, (3β)-;(3β)-28-acetate-lup-20(29)-ene-3,28-diol | | CAS: | 27686-35-7 | | MF: | C32H52O3 | | MW: | 484.75 | | EINECS: | | | Product Categories: | | | Mol File: | 27686-35-7.mol |  |
| | 28-Acetylbetulin Chemical Properties |
| Melting point | 289-291 °C | | Boiling point | 534.9±23.0 °C(Predicted) | | density | 1.022±0.06 g/cm3(Predicted) | | storage temp. | -20°C | | solubility | DMF: 1 mg/ml,DMSO: slightly soluble | | form | A crystalline solid | | pka | 15.17±0.70(Predicted) |
| | 28-Acetylbetulin Usage And Synthesis |
| Uses | 28-O-Acetylbetulin (Compound 4) is a derivative of Betulin (HY-N0083). 28-O-Acetylbetulin has anticancer activity[1]. | | Biological Activity | 28-Acetylbetulin is a lupane triterpenoid and derivative of the cholesterol biosynthesis inhibitor betulin that has been found in M. chiapensis and has anti-inflammatory and anticancer activities.1,2 It inhibits LPS-induced nitric oxide (NO) and prostaglandin E2 production by 55.9 and 69.5%, respectively, in RAW 264.7 cells (IC50s = 4.7 and 1.7 μM, respectively).1 28-Acetylbetulin induces cytotoxicity in a variety of cancer cells, including A549, HT-29, and MCF-7 cells (IC50s = 14.37, 10.96, and 11.38 μM, respectively).2 | | References | 1.Reyes, C.P., Núez, M.J., Jiménez, I.A., et al.Activity of lupane triterpenoids from Maytenus species as inhibitors of nitric oxide and prostaglandin E2Bioorg. Med. Chem.14(5)1573-1579(2006)
2.Kommera, H., Kaluderovi, G.N., Kalbitz, J., et al.Lupane triterpenoids--betulin and betulinic acid derivatives induce apoptosis in tumor cellsInvest. New Drugs29(2)266-272(2011) |
| | 28-Acetylbetulin Preparation Products And Raw materials |
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