| Company Name: |
ChemeGen |
| Tel: |
18818260767 |
| Email: |
2625930290@qq.com |
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| | Tebipenem hydrate Basic information |
| | Tebipenem hydrate Chemical Properties |
| solubility | DMSO: 1 mg/mlPBS (pH 7.2): 1 mg/ml |
| | Tebipenem hydrate Usage And Synthesis |
| Description | Tebipenem is a carbenapenem antibiotic.1,2 It is active against a panel of clinical isolates from a variety of bacterial species (MIC50s = ≤0.0039-8 µg/ml), including methicillin-resistant strains of S. aureus and S. epidermidis and penicillin-resistant S. pneumoniae.1 Tebipenem inhibits β-lactamase in a concentration-dependent manner.2 It decreases the number of colony forming units (CFUs) in the lungs in a mouse model of penicillin-resistant S. pneumoniae infection when administered at doses ranging from 0.32 to 3.2 mg/kg.1WARNING This product is not for human or veterinary use. | | References | [1] KOICHI FUJIMOTO. Novel carbapenem antibiotics for parenteral and oral applications: in vitro and in vivo activities of 2-aryl carbapenems and their pharmacokinetics in laboratory animals.[J]. Antimicrobial Agents and Chemotherapy, 2013, 57 2: 697-707. DOI: 10.1128/aac.01051-12
[2] SAUGATA HAZRA John S B Hua Xu. Tebipenem, a New Carbapenem Antibiotic, Is a Slow Substrate That Inhibits the β-Lactamase from Mycobacterium tuberculosis[J]. Biochemistry Biochemistry, 2014, 53 22: 3671-3678. DOI: 10.1021/bi500339j |
| | Tebipenem hydrate Preparation Products And Raw materials |
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