Benzenesulfonamide, 3-[6-amino-5-(2-methyl-5-oxazolyl)-3-pyridinyl]-N-(2-hydroxy-2-methylpropyl)-4-methyl-

Request For Quotation
Benzenesulfonamide, 3-[6-amino-5-(2-methyl-5-oxazolyl)-3-pyridinyl]-N-(2-hydroxy-2-methylpropyl)-4-methyl- Suppliers list
Company Name: TargetMol Chemicals Inc.
Tel: +17819995354
Email: marketing@targetmol.com
Products Intro: Product Name:PI3Kγ inhibitor 4
CAS:1821038-80-5
Package:25mg;1520USD|50mg;1980USD|100mg;2500USD
Company Name: Nantong Hanfang Biotechnology Co. , Ltd.  
Tel: hanfangpharma@126.com; 18616537568
Email: hanfangpharma@126.com
Products Intro: Product Name:Benzenesulfonamide, 3-[6-amino-5-(2-methyl-5-oxazolyl)-3-pyridinyl]-N-(2-hydroxy-2-methylpropyl)-4-methyl-
CAS:1821038-80-5
Purity:98%+ Package:1g；5g；10g；100g; 1kg
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Email: marketing@targetmol.cn
Products Intro: Product Name:PI3Kγ inhibitor 4
CAS:1821038-80-5
Package:25mg/RMB 10600;50mg/RMB 13800;100mg/RMB 17500

Benzenesulfonamide, 3-[6-amino-5-(2-methyl-5-oxazolyl)-3-pyridinyl]-N-(2-hydroxy-2-methylpropyl)-4-methyl- manufacturers

  • PI3Kγ inhibitor 4
  • PI3Kγ inhibitor 4 pictures
  • $1520.00 / 25mg
  • 2026-03-12
  • CAS:1821038-80-5
  • Min. Order:
  • Purity:
  • Supply Ability: 10g
Benzenesulfonamide, 3-[6-amino-5-(2-methyl-5-oxazolyl)-3-pyridinyl]-N-(2-hydroxy-2-methylpropyl)-4-methyl- Basic information
Product Name:Benzenesulfonamide, 3-[6-amino-5-(2-methyl-5-oxazolyl)-3-pyridinyl]-N-(2-hydroxy-2-methylpropyl)-4-methyl-
Synonyms:Benzenesulfonamide, 3-[6-amino-5-(2-methyl-5-oxazolyl)-3-pyridinyl]-N-(2-hydroxy-2-methylpropyl)-4-methyl-;PI3Kγ inhibitor 4
CAS:1821038-80-5
MF:C20H24N4O4S
MW:416.49
EINECS:
Product Categories:
Mol File:1821038-80-5.mol
Benzenesulfonamide, 3-[6-amino-5-(2-methyl-5-oxazolyl)-3-pyridinyl]-N-(2-hydroxy-2-methylpropyl)-4-methyl- Structure
Benzenesulfonamide, 3-[6-amino-5-(2-methyl-5-oxazolyl)-3-pyridinyl]-N-(2-hydroxy-2-methylpropyl)-4-methyl- Chemical Properties
Boiling point 603.6±65.0 °C(Predicted)
density 1.294±0.06 g/cm3(Predicted)
pka11.09±0.50(Predicted)
Safety Information
MSDS Information
Benzenesulfonamide, 3-[6-amino-5-(2-methyl-5-oxazolyl)-3-pyridinyl]-N-(2-hydroxy-2-methylpropyl)-4-methyl- Usage And Synthesis
UsesPI3Kγ inhibitor 4 is a potent, selective and orally active inhibitor of PI3Kγ, with an IC50 of 40 nM. PI3Kγ inhibitor 4 shows ～7, 43, and 18-fold selectivity for PI3Kγ over the α, β, and δ isoforms, respectively. PI3Kγ inhibitor 4 can be used for the research of airway inflammation[1].
in vivo

PI3Kγ inhibitor 4 (10-20 mg/kg; a single p.o.) dose dependently inhibits the amplitude of the enhanced pause (ΔPenh) response to ovalbumin in a model of airway inflammation[1].
PI3Kγ inhibitor 4 (a single p.o.) exhibits high oral bioavailability (72, 94 and 122%) and Cmax (1.53, 12.2 and 25.2 μM) following oral administration (10, 100 and 300 mg/kg) in rats[1].

IC 50PI3Kγ: 40 nM (IC50); PI3Kα: 300 nM (IC50)
References[1] Bellenie BR, et, al. Discovery and Toxicological Profiling of Aminopyridines as Orally Bioavailable Selective Inhibitors of PI3-Kinase γ. J Med Chem. 2021 Aug 26;64(16):12304-12321. DOI:10.1021/acs.jmedchem.1c00986
Benzenesulfonamide, 3-[6-amino-5-(2-methyl-5-oxazolyl)-3-pyridinyl]-N-(2-hydroxy-2-methylpropyl)-4-methyl- Preparation Products And Raw materials
Tag:Benzenesulfonamide, 3-[6-amino-5-(2-methyl-5-oxazolyl)-3-pyridinyl]-N-(2-hydroxy-2-methylpropyl)-4-methyl-(1821038-80-5) Related Product Information