1-Piperazinecarboxamide, 4-[6-methoxy-7-[3-(1-piperidinyl)propoxy]-4-quinazolinyl]-N-[4-(1-methylethoxy)phenyl]-, sulfate (1:1)

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1-Piperazinecarboxamide, 4-[6-methoxy-7-[3-(1-piperidinyl)propoxy]-4-quinazolinyl]-N-[4-(1-methylethoxy)phenyl]-, sulfate (1:1) Basic information
Product Name:1-Piperazinecarboxamide, 4-[6-methoxy-7-[3-(1-piperidinyl)propoxy]-4-quinazolinyl]-N-[4-(1-methylethoxy)phenyl]-, sulfate (1:1)
Synonyms:1-Piperazinecarboxamide, 4-[6-methoxy-7-[3-(1-piperidinyl)propoxy]-4-quinazolinyl]-N-[4-(1-methylethoxy)phenyl]-, sulfate (1:1);Tandutinib sulfate
CAS:387867-14-3
MF:C31H44N6O8S
MW:660.79
EINECS:
Product Categories:
Mol File:387867-14-3.mol
1-Piperazinecarboxamide, 4-[6-methoxy-7-[3-(1-piperidinyl)propoxy]-4-quinazolinyl]-N-[4-(1-methylethoxy)phenyl]-, sulfate (1:1) Structure
1-Piperazinecarboxamide, 4-[6-methoxy-7-[3-(1-piperidinyl)propoxy]-4-quinazolinyl]-N-[4-(1-methylethoxy)phenyl]-, sulfate (1:1) Chemical Properties
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MSDS Information
1-Piperazinecarboxamide, 4-[6-methoxy-7-[3-(1-piperidinyl)propoxy]-4-quinazolinyl]-N-[4-(1-methylethoxy)phenyl]-, sulfate (1:1) Usage And Synthesis
UsesTandutinib (MLN518) sulfate is a potent and selective inhibitor of the FLT3 with an IC50 of 0.22 μM, and also inhibits c-Kit and PDGFR with IC50s of 0.17 μM and 0.20 μM, respectively. Tandutinib sulfate can be used for acute myelogenous leukemia (AML)[1][2]. Tandutinib sulfate has the ability to cross the blood-brain barrier[3].
References[1] Kelly LM, et al. CT53518, a novel selective FLT3 antagonist for the treatment of acute myelogenous leukemia (AML). Cancer Cell, 2002, 1(5), 421-432. DOI:10.1016/s1535-6108(02)00070-3
[2] Griswold IJ, et al. Effects of MLN518, a dual FLT3 and KIT inhibitor, on normal and malignant hematopoiesis. Blood, 2004, 104(9), 2912-2918. DOI:10.1182/blood-2003-05-1669
[3] Yang JJ, et al. P-glycoprotein and breast cancer resistance protein affect disposition of tandutinib, a tyrosine kinase inhibitor. Drug Metab Lett. 2010 Dec;4(4):201-12. DOI:10.2174/187231210792928279
1-Piperazinecarboxamide, 4-[6-methoxy-7-[3-(1-piperidinyl)propoxy]-4-quinazolinyl]-N-[4-(1-methylethoxy)phenyl]-, sulfate (1:1) Preparation Products And Raw materials
Tag:1-Piperazinecarboxamide, 4-[6-methoxy-7-[3-(1-piperidinyl)propoxy]-4-quinazolinyl]-N-[4-(1-methylethoxy)phenyl]-, sulfate (1:1)(387867-14-3) Related Product Information
Doxorubicin hydrochloride CD117/C-KIT Protein, HUMAN (P10721-2, HEK293, HIS) FLT3 Protein, HUMAN (T227M, HEK293, HIS) PDGF R beta protein, human (biotinylated, HEK293, His-AVI) 2-Deoxy-D-glucose ANGIOTENSIN II, HUMAN