1-BROMO-3-(1,3-DIOXOLAN-2-YL)-4-FLUOROBENZENE manufacturers
|
| | 1-BROMO-3-(1,3-DIOXOLAN-2-YL)-4-FLUOROBENZENE Basic information | | Uses Application |
| | 1-BROMO-3-(1,3-DIOXOLAN-2-YL)-4-FLUOROBENZENE Chemical Properties |
| Boiling point | 260.0±40.0 °C(Predicted) | | density | 1.590±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C | | form | solid | | InChI | 1S/C9H8BrFO2/c10-6-1-2-8(11)7(5-6)9-12-3-4-13-9/h1-2,5,9H,3-4H2 | | InChIKey | WWJNPWYIXIIEJG-UHFFFAOYSA-N | | SMILES | FC1=CC=C(C=C1C2OCCO2)Br |
| Storage Class | 11 - Combustible Solids | | Hazard Classifications | Acute Tox. 4 Oral |
| | 1-BROMO-3-(1,3-DIOXOLAN-2-YL)-4-FLUOROBENZENE Usage And Synthesis |
| Uses | 1,1-Diethoxyethylene can be used as a pharmaceutical synthesis intermediate, such as in the preparation of the compound (3-[1,3]dioxolane-2-yl-4-fluoro-phenyl)-(8-nitro-quinoline-7-yl)-methanol. The specific steps are as follows: Magnesium (983 mg, 40.5 mmol) is suspended in anhydrous THF (30 ml). 1,2-Dibromoethane (0.17 ml, 2.02 mmol) is added, and the solution is stirred at room temperature for 20 minutes. 1,1-Diethoxyethylene (3.2 g, 1.295 mmol) is added dropwise, and the mixture is heated at 40 °C for 2 hours. After cooling to room temperature, Grignard reagent (0.43 M; 28.6 ml) is added at 0 °C to the anhydrous THF (30 ml) suspension of 8-nitroquinoline-7-carboxaldehyde 204 (2.5 g, 1.28 mmol). | | Application | 1,1-Diethoxyethylene can be used as a pharmaceutical synthesis intermediate. |
| | 1-BROMO-3-(1,3-DIOXOLAN-2-YL)-4-FLUOROBENZENE Preparation Products And Raw materials |
|