| Company Name: |
Bide Pharmatech Ltd.
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| Tel: |
400-400-164-7117 18317119277 |
| Email: |
product02@bidepharm.com |
| Products Intro: |
Product Name:1-(Quinoxalin-6-yl)ethanone
CAS:83570-42-7
Purity:98% Package:100mg;250mg;1g;5g;10g Remarks:BD261556
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Ethanone, 1-(6-quinoxalinyl)- (9CI) manufacturers
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| | Ethanone, 1-(6-quinoxalinyl)- (9CI) Basic information |
| | Ethanone, 1-(6-quinoxalinyl)- (9CI) Chemical Properties |
| Melting point | 106-108 °C(Solv: cyclohexane (110-82-7)) | | Boiling point | 318.9±22.0 °C(Predicted) | | density | 1.216±0.06 g/cm3(Predicted) | | storage temp. | Sealed in dry,Room Temperature | | pka | -0.34±0.30(Predicted) | | Appearance | Off-white to pink Solid |
| | Ethanone, 1-(6-quinoxalinyl)- (9CI) Usage And Synthesis |
| Synthesis | Methylmagnesium bromide (2 mL, 3.0 mol/L, 6 mmol) was added slowly and dropwise to an anhydrous tetrahydrofuran (10 mL) solution of quinoxaline-6-carboxylic acid methoxy-methyl-amide (1 g, 4.6 mmol) at 0°C and under nitrogen protection. The reaction solution was gradually warmed to room temperature over 2 hours. Upon completion of the reaction, the reaction was quenched with ammonium chloride solution and extracted with ethyl acetate. The organic phases were combined and concentrated to give the crude product. The crude product was purified by silica gel column chromatography to afford 1-(quinoxalin-6-yl)ethanone (600 mg, 75.7% yield). | | References | [1] Patent: WO2016/77232, 2016, A2. Location in patent: Page/Page column 25; 33; 35; 37
[2] Patent: WO2007/16525, 2007, A2. Location in patent: Page/Page column 99-101 |
| | Ethanone, 1-(6-quinoxalinyl)- (9CI) Preparation Products And Raw materials |
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