- Miltrione
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2026-06-30
- CAS:27210-57-7
- Min. Order: 1KG
- Purity: 98%
- Supply Ability: 1000kgs
- Miltrione
-
- $7.00
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2020-02-17
- CAS: 27210-57-7
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 100KG
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| | Miltrione Basic information |
| Product Name: | Miltrione | | Synonyms: | 5,6,7,8-Tetrahydro-2-isopropyl-8,8-diMethyl-3,4-phenanthrenedione;5,6,7,8-Tetrahydro-8,8-diMethyl-2-(1-Methylethyl)-3,4-phenanthrenedione;2-Isopropyl-5,6,7,8-tetrahydro-8,8-dimethylphenanthrene-3,4-dione;5,6,7,8-Tetrahydro-8,8-dimethyl-2-isopropyl-3,4-phenanthrenedione;Rosmariquinone;C13715;Miltiron;NSC 639662 | | CAS: | 27210-57-7 | | MF: | C19H22O2 | | MW: | 282.38 | | EINECS: | | | Product Categories: | Miscellaneous Natural Products;Aromatics;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals | | Mol File: | 27210-57-7.mol |  |
| | Miltrione Chemical Properties |
| Melting point | 98-100℃ (hexane ) | | Boiling point | 421.6±45.0 °C(Predicted) | | density | 1.094±0.06 g/cm3 (20 ºC 760 Torr) | | solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | | form | powder | | color | Red | | LogP | 4.916 (est) |
| | Miltrione Usage And Synthesis |
| Chemical Properties | Orange granular crystals, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from Salvia miltiorrhiza. | | Uses | An active component in Salvia miltiorrhiza that has been shown to inhibit the increase in the abundance of the mRNA for the α4 subunit of the GABAA receptor induced by ethanol withdrawal in cultured hippocampal neurons. A potential phytotherapeutic agent in the treatment of alcohol dependence. | | Definition | ChEBI: Miltirone is an abietane diterpenoid. | | in vivo | Miltirone (10-60 mg/kg, p.o.; one hour before test) increases the number of punished crossings in the four-plate test in mice[1].
| Animal Model: | Mice[1] | | Dosage: | 10, 30, 60 mg/kg | | Administration: | Oral gavage (p.o.); an hour before test | | Result: | Increased the number of punished crossings of mice in the 'Four-Plate Test'.
Showed some reversal of the effect of diazepam as expected for a partial agonist.
Produced no muscle relaxant effect and did not impair the performance of mice in the Julou-Courvoisier horizontal wire test.
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| | IC 50 | CES2: 0.04 μM (Ki) |
| | Miltrione Preparation Products And Raw materials |
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