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| | 3-Hydroxy-2-iodo-6-methylpyridine Basic information |
| | 3-Hydroxy-2-iodo-6-methylpyridine Chemical Properties |
| Melting point | 197-199 °C (lit.) | | Boiling point | 292.0±35.0 °C(Predicted) | | density | 1.8615 (estimate) | | storage temp. | Keep in dark place,Sealed in dry,Room Temperature | | pka | 5.46±0.10(Predicted) | | Appearance | White to light brown Solid | | InChI | InChI=1S/C6H6INO/c1-4-2-3-5(9)6(7)8-4/h2-3,9H,1H3 | | InChIKey | HRZOWBGCOJWHDY-UHFFFAOYSA-N | | SMILES | C1(I)=NC(C)=CC=C1O | | CAS DataBase Reference | 23003-30-7(CAS DataBase Reference) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-37/39-24/25 | | WGK Germany | 3 | | HS Code | 29333999 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| | 3-Hydroxy-2-iodo-6-methylpyridine Usage And Synthesis |
| Chemical Properties | Light yellow to yellow powder | | Synthesis | Step A: 6-Methylpyridin-3-ol (0.5 g, 4.58 mmol) was dissolved in aqueous sodium hydroxide solution (4.5 mL, 1 M, 4.5 mmol). Iodine (1.28 g, 5.2 mmol) was added to this solution and the reaction mixture was stirred overnight at room temperature. After completion of the reaction, it was neutralized with aqueous hydrochloric acid (2 M) to pH ≈ 7. A white precipitate precipitated from the reaction system and the product was collected by filtration. The solid product was washed with deionized water and dried to give 2-iodo-6-methylpyridin-3-ol (0.8 g, 50% yield). Mass spectral analysis showed m/z 236.0 [M + H]+. | | References | [1] Bioorganic and Medicinal Chemistry Letters, 1998, vol. 8, # 16, p. 2117 - 2122
[2] Patent: US9617268, 2017, B2. Location in patent: Page/Page column 400; 401
[3] Patent: EP1477186, 2004, A1. Location in patent: Page/Page column 35; 36
[4] Patent: EP1357111, 2003, A1. Location in patent: Page/Page column 54
[5] Tetrahedron, 2007, vol. 63, # 13, p. 2787 - 2797 |
| | 3-Hydroxy-2-iodo-6-methylpyridine Preparation Products And Raw materials |
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