特丁贝罗
| 中文名称 | 特丁贝罗 |
|---|---|
| 中文同义词 | 特丁贝罗;化合物 T13919;特丁贝罗,10 MM DMSO 溶液 |
| 英文名称 | Terbufibrol |
| 英文同义词 | Terbufibrol;K-11267;p-[[3-(p-t-Butylphenoxy)-2-hydroxypropyl]oxy]benzoic acid;p-[3-(p-tert-Butylphenoxy)-2-hydroxypropoxy]benzoic acid;Reaxys ID: 2949416;Benzoic acid, 4-[3-[4-(1,1-dimethylethyl)phenoxy]-2-hydroxypropoxy]-;Terbufibrol, 10 mM in DMSO |
| CAS号 | 56488-59-6 |
| 分子式 | C20H24O5 |
| 分子量 | 344.4 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 56488-59-6.mol |
| 结构式 |  |
特丁贝罗 性质
| 沸点 | 439.5°C (rough estimate) |
|---|---|
| 密度 | 1.1444 (rough estimate) |
| 折射率 | 1.5400 (estimate) |
| 储存条件 | Store at -20°C |
| 溶解度 | 溶于二甲基亚砜 |
| 形态 | Solid |
| 酸度系数(pKa) | 4.41±0.10(Predicted) |
| 颜色 | White to off-white |
Terbufibrol (20-200 mg/kg) is active in lowering serum TC in animals on all 3 diets, but the extent of cholesterol reduction varies in the order cholesterol (HC)>high protein and fat diet (HPF)>N (max. reductions: 154, 80, and 70%, respectively). Clofibrate (200 mg/kg) decreases TC by a maximum of 28% with the HPF-diet and 13% with the N-diet but is inactive with the HC-diet. Cholestyramine (400 mg/kg/day) is inactive in HPF-fed animals but reduces TC in HC-fed animals by 45%. With the HPF-diet nicotinic acid (200 mg/kg) is inactive. Terbufibrol lowers HDL, HDL-TC, LDL, LDL-TC and LDL-TC/PL in animals fed HPF-diet. A greater decrease of LDL-TC occurres with increasing dose. The main effect of Clofibrate (200 mg/kg) is to reduce HDL and HDL-TC and to increase LDL.