| Company Name: |
Bide Pharmatech Ltd.
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| Tel: |
400-1647117 13681763483 |
| Email: |
product02@bidepharm.com |
| Products Intro: |
Product Name:4-(2,5-Diazabicyclo[2.2.2]octan-2-yl)-6-(2-methoxy-5-(trifluoromethyl)phenyl)thieno[2,3-d]pyrimidine
CAS:2765254-39-3
Purity:98% Package:1mg;5mg;10mg;25mg;50mg Remarks:BD01515717
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| Company Name: |
TargetMol Chemicals Inc.
|
| Tel: |
4008200310 |
| Email: |
marketing@tsbiochem.com |
| Products Intro: |
Product Name:KRAS G12D inhibitor 14
CAS:2765254-39-3
Purity:99.39% Package:1mg/RMB 1780
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2,5-Diazabicyclo[2.2.2]octane, 2-[6-[2-methoxy-5-(trifluoromethyl)phenyl]thieno[2,3-d]pyrimidin-4-yl]- manufacturers
- KRAS G12D inhibitor 14
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- $299.00 / 1mg
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2025-09-18
- CAS:2765254-39-3
- Min. Order:
- Purity: 100.00%
- Supply Ability: 10g
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| | 2,5-Diazabicyclo[2.2.2]octane, 2-[6-[2-methoxy-5-(trifluoromethyl)phenyl]thieno[2,3-d]pyrimidin-4-yl]- Basic information |
| | 2,5-Diazabicyclo[2.2.2]octane, 2-[6-[2-methoxy-5-(trifluoromethyl)phenyl]thieno[2,3-d]pyrimidin-4-yl]- Chemical Properties |
| Boiling point | 550.7±50.0 °C(Predicted) | | density | 1.369±0.06 g/cm3(Predicted) | | pka | 8.57±0.20(Predicted) | | form | Solid | | color | Off-white to light yellow |
| | 2,5-Diazabicyclo[2.2.2]octane, 2-[6-[2-methoxy-5-(trifluoromethyl)phenyl]thieno[2,3-d]pyrimidin-4-yl]- Usage And Synthesis |
| Uses | KRAS G12D inhibitor 14 is a potent KRAS G12D inhibitor with a KD of 33 nM for binding to KRAS G12D protein. KRAS G12D inhibitor 14 decreases the active form of KRAS G12D (KRAS G12D-GTP) but not KRAS G13D[1]. | | in vivo | KRAS G12D inhibitor 14 (compound KD-8) (40 mg/kg or 60 mg/kg; i.p.) exhibits significant antitumor efficacy in a CT26 tumor model with a tumor growth inhibition (TGI) of 42% or 53% without causing apparent toxicity[1]. | | IC 50 | KRas G12D: 33 nM (Kd) | | References | [1] Li L, et al. Discovery of Thieno[2,3-d]pyrimidine-based KRAS G12D inhibitors as potential anticancer agents via combinatorial virtual screening. Eur J Med Chem. 2022;233:114243. DOI:10.1016/j.ejmech.2022.114243 |
| | 2,5-Diazabicyclo[2.2.2]octane, 2-[6-[2-methoxy-5-(trifluoromethyl)phenyl]thieno[2,3-d]pyrimidin-4-yl]- Preparation Products And Raw materials |
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