- HTHQ
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- $37.00 / 10mg
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2025-09-22
- CAS:148081-72-5
- Min. Order:
- Purity: 98.78%
- Supply Ability: 10g
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| | 1-O-Hexyl-2,3,5-trimethylhydroquinone Basic information |
| | 1-O-Hexyl-2,3,5-trimethylhydroquinone Chemical Properties |
| Melting point | 72.5-73°C | | Boiling point | 357.8±37.0 °C(Predicted) | | density | 0.971±0.06 g/cm3(Predicted) | | storage temp. | Inert atmosphere,2-8°C | | solubility | Chloroform：soluble | | pka | 11.22±0.30(Predicted) | | form | powder to crystal | | color | White to Light yellow to Dark green | | LogP | 5.255 (est) |
| | 1-O-Hexyl-2,3,5-trimethylhydroquinone Usage And Synthesis |
| Chemical Properties | Pale Yellow Low Melting Solid | | Uses | HTHQ (1-O-hexyl-2,3,5-trimethylhydroquinone) is a potent lipophilic phenolic antioxidant. HTHQ has considerable anti-oxidative activity by directly reacting with reactive oxygen species (ROS) and scavenging ROS to form more stable free radicals[1][2]. | | in vivo | HTHQ (50-200 mg/kg; oral administration; for 4 weeks; specific pathogen-free male Sprague Dawley rats) treatment significantly improves liver weight and serum chemistry level. HTHQ reduces hydroxyproline and malondialdehyde level in the liver. HTHQ treatment also reduces fibrotic septa. HTHQ administration shows reduced mRNA level of PDGF (Plateletderived growth factor) , α-SMA (α-smooth muscle actin) and TGF-β (transforming growth factor-β) than DMN-induced hepetic fibrosis animals in the liver tissue[2]. | Animal Model: | 48 specific pathogen-free male Sprague Dawley (SD) rats (6-week-old ) with dimethylnitrosamine (DMN) [2] | | Dosage: | 50 mg/kg, 100 mg/kg, 200 mg/kg | | Administration: | Oral administration; for 4 weeks | | Result: | Improved against DMN-induced liver fibrosis in male SD rats.
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| | References | [1] Park HJ, et al. 1-O-Hexyl-2,3,5-Trimethylhydroquinone Ameliorates l-DOPA-Induced Cytotoxicity in PC12 Cells. Molecules. 2019 Mar 1;24(5). pii: E867. DOI:10.3390/molecules24050867
[2] Jung YR et al. Inhibitory Effect of 1-O-Hexyl-2,3,5-Trimethylhydroquinone on Dimethylnitrosamine-induced Liver Fibrosis in Male SD Rats. Toxicol Res. 2010 Sep;26(3):193-201. DOI:10.5487/TR.2010.26.3.193 |
| | 1-O-Hexyl-2,3,5-trimethylhydroquinone Preparation Products And Raw materials |
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