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| | 5,6,7,7a-Tetrahydrothieno[3,2-c]pyridine-2(4H)-one hydrochloride Basic information |
| Product Name: | 5,6,7,7a-Tetrahydrothieno[3,2-c]pyridine-2(4H)-one hydrochloride | | Synonyms: | 5,6,7,7a-Tetrahydro-thieno[3,2-c]pyridin-2(4H)-one Hydrochloride;5,6,7,7a-Tetrahydro-thieno[3,2-c]pyridinone Hydrochloride;5,6,7,7a-Tetrahydrothieno[3,2-c]pyridine-2(4H)-one hydrochloride;2-oxo-2,4,5,6,7,7a-hexahydrothieno [3,2-c] pyridine. Hydrochloride;5,6,7,7a-Tetrahydrothieno[3,2-c]pyridin-2(4H)-one HCL;5,6,7,7a-Tetrahydrothieno[3,2-c]pyridine-2(4H)-one hydrochloride prasugrel intermediate I;5,6,7,7a-Tetrahydro-4H-thieno[3,2-c] 2-pyridone hydrochloride;Pragrael intermediate | | CAS: | 115473-15-9 | | MF: | C7H10ClNOS | | MW: | 191.67 | | EINECS: | 601-365-4 | | Product Categories: | Heterocyclic Compounds;Heterocycles;Sulfur & Selenium Compounds | | Mol File: | 115473-15-9.mol | ![5,6,7,7a-Tetrahydrothieno[3,2-c]pyridine-2(4H)-one hydrochloride Structure](CAS/GIF/115473-15-9.gif) |
| | 5,6,7,7a-Tetrahydrothieno[3,2-c]pyridine-2(4H)-one hydrochloride Chemical Properties |
| Melting point | 2100C (dec) | | storage temp. | Inert atmosphere,Store in freezer, under -20°C | | solubility | DMSO, Methanol, Water | | form | Solid | | color | Light Tan | | InChI | InChI=1S/C7H9NOS.ClH/c9-7-3-5-4-8-2-1-6(5)10-7;/h3,6,8H,1-2,4H2;1H | | InChIKey | PUQKTVAKLPDUAW-UHFFFAOYSA-N | | SMILES | O=C1SC2CCNCC2=C1.Cl | | CAS DataBase Reference | 115473-15-9(CAS DataBase Reference) |
| Safety Statements | 24/25 | | HazardClass | IRRITANT | | HS Code | 29349990 |
| | 5,6,7,7a-Tetrahydrothieno[3,2-c]pyridine-2(4H)-one hydrochloride Usage And Synthesis |
| Chemical Properties | Cream Solid | | Uses | Solifenacin intermediate | | Uses | An intermediate in the synthesis of Prasugrel (P701150). | | Synthesis |
Hydrochloride (0.32 ml) was added in a solution of 5-Triphenyl methyl-tetrahydro-5, 6, 7,7a 4H- theino-[3,2-c]- pyridone-2 (100 g, 0.25 moles) in acetone (500 ml) at 25 °C. Stir the reaction mass for 1 hr at 50 °C, then cool the reaction mass to 25 °C and stir for 8 to 10 hrs at 25 °C. Filter the product and wash it with acetone. Dry the material under vacuum at 60 °C to obtain 5, 6, 7,7a -Tetrahydro-4H- theino-[3,2-c]- pyridone-2 hydrochloride (42 g, 99percent).
| | References | [1] Patent: WO2012/1486, 2012, A1. Location in patent: Page/Page column 20
[2] Journal of Organic Chemistry, 2015, vol. 80, # 14, p. 7019 - 7032
[3] Patent: WO2009/62044, 2009, A2. Location in patent: Page/Page column 40
[4] Patent: WO2011/42918, 2011, A2. Location in patent: Page/Page column 43-44
[5] Patent: WO2011/92720, 2011, A2. Location in patent: Scheme 1 |
| | 5,6,7,7a-Tetrahydrothieno[3,2-c]pyridine-2(4H)-one hydrochloride Preparation Products And Raw materials |
| Raw materials | 5,6,7,7a-Tetrahydro-5-(triphenylmethyl)thieno[3,2-c]pyridinone-->4,5,6,7-Tetrahydro-5-(triphenylmethyl)thieno[3,2-c]pyridine-->Hydrochloric acid-->Water-->Acetone | | Preparation Products | 5,6,7,7a-Tetrahydro-5-(triphenylmethyl)thieno[3,2-c]pyridinone |
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