Urea, N-[6-[4-[(1R)-2-hydroxy-1-methylethyl]-4H-1,2,4-triazol-3-yl]-2-pyridinyl]-N'-pyrazolo[1,5-a]pyridin-2-yl-

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Urea, N-[6-[4-[(1R)-2-hydroxy-1-methylethyl]-4H-1,2,4-triazol-3-yl]-2-pyridinyl]-N'-pyrazolo[1,5-a]pyridin-2-yl- Suppliers list
Company Name: TargetMol Chemicals Inc.  
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Company Name: TargetMol Chemicals Inc.  
Tel: 13564774135
Email: marketing@targetmol.com

Urea, N-[6-[4-[(1R)-2-hydroxy-1-methylethyl]-4H-1,2,4-triazol-3-yl]-2-pyridinyl]-N'-pyrazolo[1,5-a]pyridin-2-yl- manufacturers

  • ASK1-IN-3
  • ASK1-IN-3 pictures
  • $2140.00
  • 2026-04-20
  • CAS:2426705-19-1
  • Purity:
  • Supply Ability: 10g
Urea, N-[6-[4-[(1R)-2-hydroxy-1-methylethyl]-4H-1,2,4-triazol-3-yl]-2-pyridinyl]-N'-pyrazolo[1,5-a]pyridin-2-yl- Basic information
Product Name:Urea, N-[6-[4-[(1R)-2-hydroxy-1-methylethyl]-4H-1,2,4-triazol-3-yl]-2-pyridinyl]-N'-pyrazolo[1,5-a]pyridin-2-yl-
Synonyms:Urea, N-[6-[4-[(1R)-2-hydroxy-1-methylethyl]-4H-1,2,4-triazol-3-yl]-2-pyridinyl]-N'-pyrazolo[1,5-a]pyridin-2-yl-;ASK1-IN-3
CAS:2426705-19-1
MF:C18H18N8O2
MW:378.39
EINECS:
Product Categories:
Mol File:2426705-19-1.mol
Urea, N-[6-[4-[(1R)-2-hydroxy-1-methylethyl]-4H-1,2,4-triazol-3-yl]-2-pyridinyl]-N'-pyrazolo[1,5-a]pyridin-2-yl- Structure
Urea, N-[6-[4-[(1R)-2-hydroxy-1-methylethyl]-4H-1,2,4-triazol-3-yl]-2-pyridinyl]-N'-pyrazolo[1,5-a]pyridin-2-yl- Chemical Properties
density 1.50±0.1 g/cm3(Predicted)
pka7.90±0.46(Predicted)
Safety Information
MSDS Information
Urea, N-[6-[4-[(1R)-2-hydroxy-1-methylethyl]-4H-1,2,4-triazol-3-yl]-2-pyridinyl]-N'-pyrazolo[1,5-a]pyridin-2-yl- Usage And Synthesis
UsesASK1-IN-3 is a potent and selective ASK1 kinase inhibitor with IC50 of 33.8 nM, as well as inhibits several cell cycle regulating kinases. ASK1-IN-3 has strong HepG2 cancer cells apoptosis induction and potent cell cycle arrest activities[1].
IC 50ASK1: 33.8 nM (IC50)
References[1] Zhang S, Huang C, Lyu X, et al. Discovery of a 2-pyridinyl urea-containing compound YD57 as a potent inhibitor of apoptosis signal-regulating kinase 1 (ASK1). Eur J Med Chem. 2020;195:112277. DOI:10.1016/j.ejmech.2020.112277
Urea, N-[6-[4-[(1R)-2-hydroxy-1-methylethyl]-4H-1,2,4-triazol-3-yl]-2-pyridinyl]-N'-pyrazolo[1,5-a]pyridin-2-yl- Preparation Products And Raw materials
Tag:Urea, N-[6-[4-[(1R)-2-hydroxy-1-methylethyl]-4H-1,2,4-triazol-3-yl]-2-pyridinyl]-N'-pyrazolo[1,5-a]pyridin-2-yl-(2426705-19-1) Related Product Information
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