- Tetrac
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- $39.00 / 10mg
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2025-10-31
- CAS:67-30-1
- Min. Order:
- Purity: 99.04%
- Supply Ability: 10g
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| | 3,3',5,5'-TETRAIODOTHYRO-ACETIC ACID Basic information |
| Product Name: | 3,3',5,5'-TETRAIODOTHYRO-ACETIC ACID | | Synonyms: | 3,3’,5,5’-tetraiodo-thyroaceticaci;3,5-diiodo-4-(4-hydroxy-3,5-diiodophenoxy)-benzeneaceticaci;3,5-diiodo-4-(4-hydroxy-3,5-diiodophenoxy)benzeneaceticacid;acide3,5,3’,5’-tetraiodothyroacetique;Levothyroxine – Impurity D;Liothyronine EP Impurity D;tetraiodothyroaceticacid;4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenylacetic acid | | CAS: | 67-30-1 | | MF: | C14H8I4O4 | | MW: | 747.83 | | EINECS: | 200-649-1 | | Product Categories: | Aromatic Phenylacetic Acids and Derivatives;Aromatics;Drug Analogues;Impurities;Intermediates & Fine Chemicals;Pharmaceuticals | | Mol File: | 67-30-1.mol |  |
| | 3,3',5,5'-TETRAIODOTHYRO-ACETIC ACID Chemical Properties |
| Melting point | 219-220 °C (decomp) | | Boiling point | 544.8±50.0 °C(Predicted) | | density | 2.727±0.06 g/cm3(Predicted) | | storage temp. | Keep in dark place,Sealed in dry,Store in freezer, under -20°C | | solubility | acetone: soluble19.60 - 20.40mg/mL, clear, colorless (or faintly yellow to yellow) | | form | powder to crystal | | pka | 3.98±0.10(Predicted) | | color | White to Yellow to Green | | InChI | InChI=1S/C14H8I4O4/c15-8-4-7(5-9(16)13(8)21)22-14-10(17)1-6(2-11(14)18)3-12(19)20/h1-2,4-5,21H,3H2,(H,19,20) | | InChIKey | PPJYSSNKSXAVDB-UHFFFAOYSA-N | | SMILES | C1(CC(O)=O)=CC(I)=C(OC2=CC(I)=C(O)C(I)=C2)C(I)=C1 |
| Hazard Codes | T+ | | Risk Statements | 28 | | Safety Statements | 45 | | RIDADR | UN 2811 6.1/PG 1 | | WGK Germany | 3 | | RTECS | CY1585800 | | HS Code | 2916.39.7900 | | HazardClass | 6.1 |
| | 3,3',5,5'-TETRAIODOTHYRO-ACETIC ACID Usage And Synthesis |
| Uses | Thyroid hormone analogue | | Uses | 3,3′,5,5′-Tetraiodothyroacetic acid has been used:
- as a positive control to study the effects of ioxynil (IOX)
- diethylstilbestrol (DES) exposure on zebrafish embryos
- to study its effects on long-term potentiation (LTP) and long-term depression (LTD) in the dentate gyrus in urethane-anesthetized male rats
- to determine its influence on the actions of thyroid-stimulating hormone
- thyroid-stimulating immunoglobulins in orbital fibroblast
| | Definition | ChEBI: A monocarboxylic acid that is thyroacetic acid carrying four iodo substituents at positions 3, 3', 5 and 5'. | | Biochem/physiol Actions | Studies in rats have reported that Tetrac may regulate TSH secretion under in vivo conditions1. | | in vivo | Tetrac (35 μg; p.o. for 40 days) inhibits tumor inoculation, growth and integrin expression in mice[4]. | Animal Model: | Wild-type male Balb/C mice aged 8 weeks are inoculated with 102B16F10 or B16LS9 cells[4] | | Dosage: | 35 μg per day | | Administration: | P.o. (added to the drinking water) daily for 40 days | | Result: | Delayed the onset of ocular melanoma.
Reduced the S-100 and integrin staining level in the B16F10 mice model.
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| | 3,3',5,5'-TETRAIODOTHYRO-ACETIC ACID Preparation Products And Raw materials |
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