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| | Benzeneacetic acid, 2,5-dichloro- Basic information |
| Product Name: | Benzeneacetic acid, 2,5-dichloro- | | Synonyms: | Benzeneacetic acid, 2,5-dichloro-;2,5-Dichlorobenzeneacetic acid;2-(2,5-Dichlorophenyl)ethanoic acid;NSC 3045;JR-14007, 2-(2,5-Dichlorophenyl)acetic acid, 95%;Guanfacine Impurity 17 | | CAS: | 5398-79-8 | | MF: | C8H6Cl2O2 | | MW: | 205.04 | | EINECS: | | | Product Categories: | | | Mol File: | 5398-79-8.mol |  |
| | Benzeneacetic acid, 2,5-dichloro- Chemical Properties |
| Melting point | 105-107℃ | | Boiling point | 322.5±27.0 °C(Predicted) | | density | 1.456 | | storage temp. | Sealed in dry,Room Temperature | | pka | 3.87±0.10(Predicted) | | Appearance | White to off-white Solid |
| | Benzeneacetic acid, 2,5-dichloro- Usage And Synthesis |
| Synthesis | The general procedure for the synthesis of 2,5-dichlorophenylacetic acid from 2,5-dichlorophenylacetonitrile was as follows: concentrated sulfuric acid (8 mL) was added dropwise to a stirring solution of 2-(2,5-dichlorophenyl)acetonitrile (700 mg, 3.76 mmol, 1.00 equiv.) in water (6 mL). The reaction mixture was stirred in an oil bath at 110 °C for 3 hours. Upon completion of the reaction, the reaction solution was diluted with distilled water (100 mL) and subsequently extracted with dichloromethane (3 x 50 mL). The organic layers were combined, washed with saturated saline (3 x 100 mL) and dried with anhydrous sodium sulfate. Finally, the solvent was removed by concentration under reduced pressure to give 700 mg (91% yield) of 2,5-dichlorophenylacetic acid as a white solid. | | References | [1] Patent: WO2013/96771, 2013, A1. Location in patent: Page/Page column 165
[2] Phytochemistry (Elsevier), 1988, vol. 27, # l, p. 51 - 72
[3] Patent: WO2008/91594, 2008, A2. Location in patent: Page/Page column 73
[4] Patent: WO2007/14290, 2007, A2. Location in patent: Page/Page column 56 |
| | Benzeneacetic acid, 2,5-dichloro- Preparation Products And Raw materials |
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