- 1-Boc-3-hydroxypiperidine
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- $0.00 / 1kg
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2025-12-29
- CAS:85275-45-2
- Min. Order: 1kg
- Purity: 98%
- Supply Ability: according to customer's requirements
- 1-Boc-3-hydroxypiperidine
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- $5.00 / 1KG
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2025-09-25
- CAS:85275-45-2
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: g-kg-tons, free sample is available
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| | 1-Boc-3-hydroxypiperidine Basic information |
| | 1-Boc-3-hydroxypiperidine Chemical Properties |
| Melting point | 65-67°C | | Boiling point | 292.3±33.0 °C(Predicted) | | density | 1.107±0.06 g/cm3(Predicted) | | storage temp. | Sealed in dry,Room Temperature | | form | powder to crystal | | pka | 14.74±0.20(Predicted) | | color | White to Almost white | | BRN | 4180859 | | InChI | InChI=1S/C10H19NO3/c1-10(2,3)14-9(13)11-6-4-5-8(12)7-11/h8,12H,4-7H2,1-3H3 | | InChIKey | UIJXHKXIOCDSEB-UHFFFAOYSA-N | | SMILES | N1(C(OC(C)(C)C)=O)CCCC(O)C1 | | CAS DataBase Reference | 85275-45-2(CAS DataBase Reference) |
| | 1-Boc-3-hydroxypiperidine Usage And Synthesis |
| Chemical Properties | White solid | | Uses | It is a pharmaceutical intermediate. | | Synthesis | 1) At room temperature, 3-hydroxypiperidine (5.00 g) was dissolved in methanol (50 mL), to which a methanol (50 mL) solution of triethylamine (15.2 mL) and di-tert-butyl dicarbonate (11.9 g) were sequentially added. The reaction mixture was stirred for 15 hours. After completion of the reaction, the solvent was removed by evaporation under reduced pressure and the resulting residue was purified by silica gel column chromatography (eluent: ethyl acetate-chloroform) to afford tert-butyl 3-hydroxypiperidine-1-carboxylate as a white solid (9.86 g, 99% yield). The product was characterized by 1H-NMR (400 MHz, CDCl3) and EI-MS: 1H-NMR δ: 1.36-1.55 (2H, m), 1.45 (9H, s), 1.71-1.78 (1H, m), 1.88 (1H, m), 3.02-3.13 (2H, m), 3.52 (1H, m), 3.72-3.76 (2H, m); EI-MS m/z: 201 (M+). | | References | [1] Journal of Medicinal Chemistry, 2006, vol. 49, # 11, p. 3159 - 3171
[2] Patent: EP1762568, 2007, A1. Location in patent: Page/Page column 49-50
[3] Patent: EP1785418, 2007, A1. Location in patent: Page/Page column 47
[4] Patent: EP1107965, 2004, B1. Location in patent: Page 13
[5] Tetrahedron, 2011, vol. 67, # 7, p. 1485 - 1500 |
| | 1-Boc-3-hydroxypiperidine Preparation Products And Raw materials |
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