1H-Indole-2-carboxamide, 5-[2-(dimethylamino)ethoxy]-N-[3-[4-[(hydroxyamino)carbonyl]phenyl]-2-propyn-1-yl]-, hydrochloride (1:1)

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1H-Indole-2-carboxamide, 5-[2-(dimethylamino)ethoxy]-N-[3-[4-[(hydroxyamino)carbonyl]phenyl]-2-propyn-1-yl]-, hydrochloride (1:1) Suppliers list
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Products Intro: Product Name:CRA-026440 hydrochloride
CAS:847459-98-7
Purity:99.78% Package:1mg;70USD|5mg;173USD|10mg;273USD
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354;
Email: support@targetmol.com
Products Intro: Product Name:CRA-026440 hydrochloride
CAS:847459-98-7
Purity:99.78% Package:1mg;70USD|5mg;173USD|10mg;273USD
Company Name: Shanghai Yifei Biotechnology Co. , Ltd.  
Tel: 021-65675885 18964387627
Email: customer_service@efebio.com
Products Intro: Product Name:CRA-026440 hydrochloride
CAS:847459-98-7
Purity:99% Package:1mg;5mg;10mg
Company Name: Beijing Boorsen Biotechnology Co., Ltd  
Tel: 400-901-9800 18611424007
Email: cis@bioss.com.cn
Products Intro: Product Name:CRA-026440 hydrochloride
Purity:0.9978 Package:1mg;1mL x 10mM (in DMSO) Remarks:D55869
Company Name: RD International Technology Co., Limited  
Tel: 18024082417
Email: market@ubiochem.com
Products Intro: Product Name:HDAC/BET-IN-1
CAS:847459-98-7
Purity:5mg;10mg;50mg;100mg;250mg;500mg;1g Package:5mg;10mg;50mg;100mg;250mg;500mg;1g

1H-Indole-2-carboxamide, 5-[2-(dimethylamino)ethoxy]-N-[3-[4-[(hydroxyamino)carbonyl]phenyl]-2-propyn-1-yl]-, hydrochloride (1:1) manufacturers
1H-Indole-2-carboxamide, 5-[2-(dimethylamino)ethoxy]-N-[3-[4-[(hydroxyamino)carbonyl]phenyl]-2-propyn-1-yl]-, hydrochloride (1:1) Basic information
Product Name:1H-Indole-2-carboxamide, 5-[2-(dimethylamino)ethoxy]-N-[3-[4-[(hydroxyamino)carbonyl]phenyl]-2-propyn-1-yl]-, hydrochloride (1:1)
Synonyms:1H-Indole-2-carboxamide, 5-[2-(dimethylamino)ethoxy]-N-[3-[4-[(hydroxyamino)carbonyl]phenyl]-2-propyn-1-yl]-, hydrochloride (1:1);CRA-026440 hydrochloride;HDAC/BET-IN-1;CRA-026440 hydrochloride, 10 mM in DMSO
CAS:847459-98-7
MF:C23H25ClN4O4
MW:456.93
EINECS:
Product Categories:
Mol File:847459-98-7.mol
1H-Indole-2-carboxamide, 5-[2-(dimethylamino)ethoxy]-N-[3-[4-[(hydroxyamino)carbonyl]phenyl]-2-propyn-1-yl]-, hydrochloride (1:1) Structure
1H-Indole-2-carboxamide, 5-[2-(dimethylamino)ethoxy]-N-[3-[4-[(hydroxyamino)carbonyl]phenyl]-2-propyn-1-yl]-, hydrochloride (1:1) Chemical Properties
form Solid
color White to off-white
Safety Information
MSDS Information
1H-Indole-2-carboxamide, 5-[2-(dimethylamino)ethoxy]-N-[3-[4-[(hydroxyamino)carbonyl]phenyl]-2-propyn-1-yl]-, hydrochloride (1:1) Usage And Synthesis
UsesCRA-026440 hydrochloride is a potent, broad-spectrum HDAC (HDAC) inhibitor. The Ki values against recombinant HDAC isoenzymes HDAC1, HDAC2, HDAC3, HDAC6, HDAC8, and HDAC10 are 4 nM, 14 nM, 11 nM, 15 nM, 7 nM, and 20 nM respectively. CRA-026440 hydrochloride shows antitumor and antiangiogenic activities[1]. CRA-026440 (hydrochloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
in vivo

CRA-026440 hydrochloride (100 mg/kg; i.v.; daily; for three consecutive days) results in a statistically significant reduction in tumor growth in mice harboring HCT116 or U937 human tumor xenografts[1].

Animal Model:HCT-116 tumor-bearing nude mice[1]
Dosage:100 mg/kg
Administration:i.v.; daily; for three consecutive days
Result:Resulted in a statistically significant reduction in tumor growth.
IC 50HDAC1: 4 nM (IC50); HDAC2: 14 nM (IC50); HDAC3/SMRT: 11 nM (IC50); HDAC6: 15 nM (IC50); HDAC8: 7 nM (IC50); HDAC10: 20 nM (IC50)
References[1] [1]Cao ZA, et al. CRA-026440: a potent, broad-spectrum, hydroxamic histone deacetylase inhibitor with antiproliferative and antiangiogenic activity in vitro and in vivo. Mol Cancer Ther. 2006 Jul;5(7):1693-701. DOI:10.1158/1535-7163.MCT-06-0042
1H-Indole-2-carboxamide, 5-[2-(dimethylamino)ethoxy]-N-[3-[4-[(hydroxyamino)carbonyl]phenyl]-2-propyn-1-yl]-, hydrochloride (1:1) Preparation Products And Raw materials
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