1H-Pyrazole-3-carboxamide, N-[5-[(6,7-dimethoxy-4-quinolinyl)oxy]-2-pyridinyl]-1-ethyl-5-methyl-4-(2,2,2-trifluoroethoxy)-

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1H-Pyrazole-3-carboxamide, N-[5-[(6,7-dimethoxy-4-quinolinyl)oxy]-2-pyridinyl]-1-ethyl-5-methyl-4-(2,2,2-trifluoroethoxy)- Suppliers list
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1H-Pyrazole-3-carboxamide, N-[5-[(6,7-dimethoxy-4-quinolinyl)oxy]-2-pyridinyl]-1-ethyl-5-methyl-4-(2,2,2-trifluoroethoxy)- manufacturers
1H-Pyrazole-3-carboxamide, N-[5-[(6,7-dimethoxy-4-quinolinyl)oxy]-2-pyridinyl]-1-ethyl-5-methyl-4-(2,2,2-trifluoroethoxy)- Basic information
Product Name:1H-Pyrazole-3-carboxamide, N-[5-[(6,7-dimethoxy-4-quinolinyl)oxy]-2-pyridinyl]-1-ethyl-5-methyl-4-(2,2,2-trifluoroethoxy)-
Synonyms:1H-Pyrazole-3-carboxamide, N-[5-[(6,7-dimethoxy-4-quinolinyl)oxy]-2-pyridinyl]-1-ethyl-5-methyl-4-(2,2,2-trifluoroethoxy)-;Axl/Mer/CSF1R-IN-1
CAS:2394874-60-1
MF:C25H24F3N5O5
MW:531.48
EINECS:
Product Categories:
Mol File:2394874-60-1.mol
1H-Pyrazole-3-carboxamide, N-[5-[(6,7-dimethoxy-4-quinolinyl)oxy]-2-pyridinyl]-1-ethyl-5-methyl-4-(2,2,2-trifluoroethoxy)- Structure
1H-Pyrazole-3-carboxamide, N-[5-[(6,7-dimethoxy-4-quinolinyl)oxy]-2-pyridinyl]-1-ethyl-5-methyl-4-(2,2,2-trifluoroethoxy)- Chemical Properties
Boiling point 602.8±55.0 °C(Predicted)
density 1.38±0.1 g/cm3(Predicted)
pka10.57±0.70(Predicted)
Safety Information
MSDS Information
1H-Pyrazole-3-carboxamide, N-[5-[(6,7-dimethoxy-4-quinolinyl)oxy]-2-pyridinyl]-1-ethyl-5-methyl-4-(2,2,2-trifluoroethoxy)- Usage And Synthesis
UsesAxl/Mer-IN-1 (Compound 1) is an Axl/Mer receptor tyrosine kinase (Axl/Mer RTK) and CSF1R inhibitor with Kds of <0.1 μM[1].
IC 50Axl; Mer
References[1] Kiyean NAM, et al. Quinoline derivatives as inhibitors of axl/mer rtk and csf1r. Patent WO2019229251A1.
1H-Pyrazole-3-carboxamide, N-[5-[(6,7-dimethoxy-4-quinolinyl)oxy]-2-pyridinyl]-1-ethyl-5-methyl-4-(2,2,2-trifluoroethoxy)- Preparation Products And Raw materials
Tag:1H-Pyrazole-3-carboxamide, N-[5-[(6,7-dimethoxy-4-quinolinyl)oxy]-2-pyridinyl]-1-ethyl-5-methyl-4-(2,2,2-trifluoroethoxy)-(2394874-60-1) Related Product Information
AXL Protein, HUMAN (BIOTINYLATED, HEK293, HIS-AVI) AXL Protein, HUMAN (HEK293, FC) CSF1R Protein, HUMAN (HEK293, HIS-FC) CSF1R Protein, MOUSE (HEK293, FC) Mer Protein, Cynomolgus (HEK293, Fc) PF 477736