Benzamide, 2-(phenylmethoxy)-N-tricyclo[3.3.1.13,7]dec-1-yl-

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Benzamide, 2-(phenylmethoxy)-N-tricyclo[3.3.1.13,7]dec-1-yl- manufacturers
Benzamide, 2-(phenylmethoxy)-N-tricyclo[3.3.1.13,7]dec-1-yl- Basic information
Product Name:Benzamide, 2-(phenylmethoxy)-N-tricyclo[3.3.1.13,7]dec-1-yl-
Synonyms:Benzamide, 2-(phenylmethoxy)-N-tricyclo[3.3.1.13,7]dec-1-yl-;CB2R/FAAH modulator-1;CB2R/FAAHu00A0modulator-1;CB2R/FAAHu00A0modulator-1, 10 mM in DMSO;2-(Phenylmethoxy)-N-tricyclo[3.3.1.13,7]dec-1-ylbenzamide
CAS:928892-60-8
MF:C24H27NO2
MW:361.48
EINECS:
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Mol File:928892-60-8.mol
Benzamide, 2-(phenylmethoxy)-N-tricyclo[3.3.1.13,7]dec-1-yl- Structure
Benzamide, 2-(phenylmethoxy)-N-tricyclo[3.3.1.13,7]dec-1-yl- Chemical Properties
Boiling point 542.3±33.0 °C(Predicted)
density 1.19±0.1 g/cm3(Predicted)
pka14+-.0.20(Predicted)
Safety Information
MSDS Information
Benzamide, 2-(phenylmethoxy)-N-tricyclo[3.3.1.13,7]dec-1-yl- Usage And Synthesis
UsesCB2R/FAAH modulator-1 is a cannabinoid type 2 receptor (CB2R) full agonist with Kis of 14.8 nM and 241.3 nM for CB2R and CB1R, respectively. CB2R/FAAH modulator-1 is a fatty acid amide hydrolase (FAAH) inhibitor with an IC50 of 4 μM. CB2R/FAAH modulator-1 decreases pro-inflammatory and increases anti-inflammatory cytokines production[1].
IC 50CB2R: 14.8 nM (Ki); CB2R: 123.6 nM (EC50); CB1R: 241.3 nM (Ki); CB1R: 489 nM (EC50)
References[1] Francesca Intranuov, et al. Development of N-(1-Adamantyl)benzamides as Novel Anti-Inflammatory Multitarget Agents Acting as Dual Modulators of the Cannabinoid CB2 Receptor and Fatty Acid Amide Hydrolase. J Med Chem. 2023 Jan 12;66(1):235-250. DOI:10.1021/acs.jmedchem.2c01084
Benzamide, 2-(phenylmethoxy)-N-tricyclo[3.3.1.13,7]dec-1-yl- Preparation Products And Raw materials
Tag:Benzamide, 2-(phenylmethoxy)-N-tricyclo[3.3.1.13,7]dec-1-yl-(928892-60-8) Related Product Information
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