E 6123
| 中文名称 | E 6123 |
|---|---|
| 中文同义词 | 化合物 T15188;化合物 E-6123 |
| 英文名称 | E 6123 |
| 英文同义词 | E 6123;4H-Pyrido[4',3':4,5]thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine, 6-(2-chlorophenyl)-9-(cyclopropylcarbonyl)-7,8,9,10-tetrahydro-1,4-diMethyl-, (4S)- (9CI);JEQVYSUCZLYBRQ-LBPRGKRZSA-N;E ?6123,E?6123 |
| CAS号 | 131614-02-3 |
| 分子式 | C23H22ClN5OS |
| 分子量 | 451.97168 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 131614-02-3.mol |
| 结构式 |  |
E 6123 性质
| 储存条件 | Store at -20°C |
|---|---|
| 溶解度 | 溶于二甲基亚砜 |
E-6123 是一种血小板活化因子 (PAF) 受体拮抗剂。
PAF
E-6123 (E6123) partially inhibits the Thapsigargin-induced increase in the levels of interleukin-6 mRNA and interleukin-6 protein. To clarify the role of the concurrently produced cell-associated PAF in the thapsigargin-induced increase in the interleukin-6 mRNA level and interleukin-6 production, the effects of the PAF receptor antagonist E-6123 are examined. E-6123 at 1 and 10 μM partially inhibits the Thapsigargin (46.1 nM)-induced increase in the interleukin-6 mRNA level at 4 h and interleukin-6 production at 8 h.