Dopamine D4 receptor antagonist-1

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Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
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Company Name: TargetMol Chemicals Inc.  
Tel: 13564774135
Email: marketing@targetmol.com

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Dopamine D4 receptor antagonist-1 Basic information
Product Name:Dopamine D4 receptor antagonist-1
Synonyms:Dopamine D4 receptor antagonist-1
CAS:444724-92-9
MF:C18H19ClN4
MW:326.83
EINECS:
Product Categories:
Mol File:444724-92-9.mol
Dopamine D4 receptor antagonist-1 Structure
Dopamine D4 receptor antagonist-1 Chemical Properties
form Solid
color Off-white to light brown
Safety Information
MSDS Information
Dopamine D4 receptor antagonist-1 Usage And Synthesis
UsesDopamine D4 receptor antagonist-1 is a selective DRD4 antagonists, with a Ki of 9.0 nM for Hd4.2. Dopamine D4 receptor antagonist-1 can be used in study of schizophrenia[1].
in vivo

Dopamine D4 receptor antagonist-1 (10 mg/kg; i.p.; single) shows inhibitory effect on catecholaminergic systems (DOPA accumulation in the hippocampus)[1].

Animal Model:Male Long-Evans rats (180-250 g); knockout of the DA D4 receptor locus mice (D4 KO); wild type rats (WT)[1].
Dosage:10 mg/kg
Administration:Intraperitoneal injection, single.
Result:Increased DOPA accumulation in the hippocampus with no effect observed in the striatum.
IC 50hD4.2 Receptor: 9.0 nM (Ki)
References[1] Pugsley TA, et al. The discovery of PD 89211 and related compounds: selective dopamine D4 receptor antagonists. Prog Neuropsychopharmacol Biol Psychiatry. 2002 Feb;26(2):219-26. DOI:10.1016/s0278-5846(01)00252-4
Dopamine D4 receptor antagonist-1 Preparation Products And Raw materials
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