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| | ICI D1542 Basic information |
| Product Name: | ICI D1542 | | Synonyms: | ICI D1542;D 1542;D1542;ZD 1542;Ici D1542,Ici D-1542;4-Hexenoic acid, 6-[(2S,4S,5R)-2-[1-methyl-1-(4-methyl-2-nitrophenoxy)ethyl]-4-(3-pyridinyl)-1,3-dioxan-5-yl]-, (4Z)- | | CAS: | 147332-48-7 | | MF: | C25H30N2O7 | | MW: | 470.51 | | EINECS: | | | Product Categories: | | | Mol File: | 147332-48-7.mol |  |
| | ICI D1542 Chemical Properties |
| Boiling point | 661.1±50.0 °C(Predicted) | | density | 1.225±0.06 g/cm3(Predicted) | | pka | 4.59±0.10(Predicted) |
| | ICI D1542 Usage And Synthesis |
| Description | Ici D1542 is also known as ZD1542, Ici D1542 is a potent thromboxane A2 synthase inhibitor and receptor antagonist in vitro. ZD1542 is a drug that exhibits both potent,selective TXS inhibition and TXA2 receptor antagonism. | | Uses | ICI D1542 is a selective and potent inhibitor of thromboxane A2 (TXA2) synthase and the thromboxane A2 receptor (TP-receptor). ICI D1542 is effective at preventing thrombus formation by redirection of arachidonic acid metabolism[1]. | | References | [1] S J McAuliffe, et al. Redirection of arachidonic acid metabolism by ICI D1542: effects on thrombus formation in the coronary artery of the anaesthetized dog. r J Pharmacol. 1993 Apr;108(4):901-6. DOI:10.1111/j.1476-5381.1993.tb13484.x |
| | ICI D1542 Preparation Products And Raw materials |
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