LMP517

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LMP517 Suppliers list
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Email: marketing@targetmol.cn
LMP517 Basic information
Product Name:LMP517
Synonyms:LMP517
CAS:1883730-99-1
MF:C22H19FN2O5
MW:410.4
EINECS:
Product Categories:
Mol File:1883730-99-1.mol
LMP517 Structure
LMP517 Chemical Properties
Melting point 170 °C
Boiling point 701.9±60.0 °C(Predicted)
density 1.51±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted)
form Solid
pka14.78±0.10(Predicted)
color Deep purple to brown
Safety Information
MSDS Information
LMP517 Usage And Synthesis
UsesLMP517 (NSC 781517) a indenoisoquinoline, is a potent a dual TOP1 and TOP2 inhibitor. LMP517 shows better antitumor activity than its parent compound LMP744 (HY-U00248) against H82 (Small Cell Lung Cancer) xenografts. LMP517 induces TOP1 cleavage complexes (TOP1ccs) and TOP2ccs[1].
IC 50Topoisomerase I; Topoisomerase II
References[1] Marzi L, et al. The Indenoisoquinoline LMP517: A Novel Antitumor Agent Targeting both TOP1 and TOP2. Mol Cancer Ther. 2020 Aug;19(8):1589-1597. DOI:10.1158/1535-7163.MCT-19-1064
LMP517 Preparation Products And Raw materials
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