EBV lytic cycle inducer-1

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Company Name: Shanghai YuanYe Biotechnology Co., Ltd.  
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EBV lytic cycle inducer-1 Basic information
Product Name:EBV lytic cycle inducer-1
Synonyms:EBV lytic cycle inducer-1
CAS:394668-43-0
MF:C14H12BrN3O
MW:318.17
EINECS:
Product Categories:
Mol File:394668-43-0.mol
EBV lytic cycle inducer-1 Structure
EBV lytic cycle inducer-1 Chemical Properties
density 1.41±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted)
storage temp. Storage temp. 2-8°C
pka11.67±0.46(Predicted)
form Solid
color White to off-white
Safety Information
MSDS Information
EBV lytic cycle inducer-1 Usage And Synthesis
UsesEpstein-Barr virus (EBV) lytic cycle inducer-1 Dp44mT (compound C7) is an iron-chelatoe-like compound. Dp44mT cooperates with HDAC inhibitor Romidespin (HY-15149) and SAHA to induce EBV lytic cycle. Dp44mT reactivates EBV lytic cycle by activating the ERK1/2-autophagy axis in epithelial cancers[1][2].
References[1] Chung King Choi, et al. Identification of Novel Small Organic Compounds with Diverse Structures for the Induction of Epstein-Barr Virus (EBV) Lytic Cycle in EBV-Positive Epithelial Malignancies. PLoS One. 2015 Dec 30;10(12):e0145994.
[2] Stephanie Pei Tung Yiu, et al. Intracellular Iron Chelation by a Novel Compound, C7, Reactivates Epstein–Barr Virus (EBV) Lytic Cycle via the ERK-Autophagy Axis in EBV-Positive Epithelial Cancers Cancers 2018 Dec; 10(12): 505.
EBV lytic cycle inducer-1 Preparation Products And Raw materials
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Phenylmethyl (2E)-2-[1-(2-pyridinyl)ethylidene]hydrazinecarbodithioate 2-Chloro-N'-(1-(pyridin-2-yl)ethylidene)benzohydrazide Hydrazinecarboxaldehyde, [1-(2-pyridinyl)ethylidene]- (9CI) Benzamide, 3-bromo-N-[1-(2-pyridinyl)ethyl]- N'-[(E)-1-(4-aminophenyl)ethylidene]-4-chlorobenzohydrazide N'-[(E)-1-(4-aminophenyl)ethylidene]-3-chlorobenzohydrazide