2,6-Dimethyl-4-[[1-[(4-methylphenyl)sulfonyl]-1H-indol-3-yl]methyl]phenol

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2,6-Dimethyl-4-[[1-[(4-methylphenyl)sulfonyl]-1H-indol-3-yl]methyl]phenol manufacturers

  • ALK-IN-26
  • ALK-IN-26 pictures
  • $35.00
  • 2026-07-27
  • CAS:2447607-85-2
  • Purity: 99.91%
  • Supply Ability: 10g
2,6-Dimethyl-4-[[1-[(4-methylphenyl)sulfonyl]-1H-indol-3-yl]methyl]phenol Basic information
Product Name:2,6-Dimethyl-4-[[1-[(4-methylphenyl)sulfonyl]-1H-indol-3-yl]methyl]phenol
Synonyms:2,6-Dimethyl-4-[[1-[(4-methylphenyl)sulfonyl]-1H-indol-3-yl]methyl]phenol;ALK-IN-26
CAS:2447607-85-2
MF:C24H23NO3S
MW:405.51
EINECS:
Product Categories:
Mol File:2447607-85-2.mol
2,6-Dimethyl-4-[[1-[(4-methylphenyl)sulfonyl]-1H-indol-3-yl]methyl]phenol Structure
2,6-Dimethyl-4-[[1-[(4-methylphenyl)sulfonyl]-1H-indol-3-yl]methyl]phenol Chemical Properties
Boiling point 611.4±57.0 °C(Predicted)
density 1.22±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted)
pka10.69±0.25(Predicted)
form Solid
color White to off-white
Safety Information
MSDS Information
2,6-Dimethyl-4-[[1-[(4-methylphenyl)sulfonyl]-1H-indol-3-yl]methyl]phenol Usage And Synthesis
UsesALK-IN-26 is an ALK inhibitor with IC50 value of 7.0 μM for ALK tyrosine kinase. ALK-IN-26 has good pharmacokinetic properties and blood-brain barrier (BBB) permeability. ALK-IN-26 can induce apoptosis, autophagy and necrosis. ALK-IN-26 can be used in glioblastoma studies[1].
in vivo

ALK-IN-26 (5 mg/kg, i.v., single dose) has pharmacokinetic properties in male C57BL6/J mice[1].
ALK-IN-26 is (20 mg/kg, i.p., single dose) able to penetrate the blood-brain barrier in male C57BL6/J mice[1].

Pharmacokinetic parameters of C57BL6/J in male rats (n = 3) [1]

Pharmacokinetic propertyT1/2(h)Tmax(h) Cmax (ng/mL)AUC(0-8) (h*ng/mL)AUC(0-∞) (h*ng/mL)MRT(0-8) (h)MRT(0-∞) (h)V∞ (L/kg)V2 (L/kg)bioavailablity F (%)
i.v.(5mg/kg)1.130.081978.21884.88924.560.630.844.598.8938.40
i.p.(5mg/kg)3.550.58117.57339.79420.502.254.60///
Animal Model:Male C57BL/6J mice[1]
Dosage:5 mg/kg
Administration:Intravenous injection (i.v.), Single dose
Result:Could be rapidly absorbed (Tmax = 0.58 h) with an acceptable half-life (T1/2 = 3.55 h) and bioavailability (F = 38.4%).
Animal Model:Male C57BL/6J mice[1]
Dosage:20mg/kg
Administration:Intraperitoneal injection (i.p.), Single dose
Result:Could enter the body at concentrations up to 2.7μmol/kg (after 2 h administration at 20 mg/kg) and penetrate the blood-brain barrier.
References[1] Feng L, et al. Synthesis and Bioevaluation of 3-(Arylmethylene) indole Derivatives: Discovery of a Novel ALK Modulator with Antiglioblastoma Activities[J]. Journal of Medicinal Chemistry, 2023. DOI:10.1021/acs.jmedchem.3c01090
2,6-Dimethyl-4-[[1-[(4-methylphenyl)sulfonyl]-1H-indol-3-yl]methyl]phenol Preparation Products And Raw materials
Tag:2,6-Dimethyl-4-[[1-[(4-methylphenyl)sulfonyl]-1H-indol-3-yl]methyl]phenol(2447607-85-2) Related Product Information
1H-Indole-3-carboxaldehyde, 6-methoxy-1-[(4-methoxyphenyl)sulfonyl]- 1H-Indole, 4-bromo-3-methyl-1-(phenylsulfonyl)- Ethanone, 1-[1-[(4-methylphenyl)sulfonyl]-1H-indol-3-yl]- 1H-Pyrrole, 3-ethyl-1-(phenylsulfonyl)- N-(benzenesulfonyl)indole-3-carbonitrile 1H-Indole, 3-(4-methoxyphenyl)-1-(phenylsulfonyl)-