(5S,6R,7R,8S)-5,6,7,8-Tetrahydro-7,8-dihydroxy-2-[2-(3-phenoxyphenyl)ethyl]-6-(2-phenylethoxy)imidazo[1,2-a]pyridine-5-carboxylic acid

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(5S,6R,7R,8S)-5,6,7,8-Tetrahydro-7,8-dihydroxy-2-[2-(3-phenoxyphenyl)ethyl]-6-(2-phenylethoxy)imidazo[1,2-a]pyridine-5-carboxylic acid Basic information
Product Name:(5S,6R,7R,8S)-5,6,7,8-Tetrahydro-7,8-dihydroxy-2-[2-(3-phenoxyphenyl)ethyl]-6-(2-phenylethoxy)imidazo[1,2-a]pyridine-5-carboxylic acid
Synonyms:(5S,6R,7R,8S)-5,6,7,8-Tetrahydro-7,8-dihydroxy-2-[2-(3-phenoxyphenyl)ethyl]-6-(2-phenylethoxy)imidazo[1,2-a]pyridine-5-carboxylic acid;HPSE1-IN-1
CAS:2876926-29-1
MF:C30H30N2O6
MW:514.57
EINECS:
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Mol File:2876926-29-1.mol
(5S,6R,7R,8S)-5,6,7,8-Tetrahydro-7,8-dihydroxy-2-[2-(3-phenoxyphenyl)ethyl]-6-(2-phenylethoxy)imidazo[1,2-a]pyridine-5-carboxylic acid Structure
(5S,6R,7R,8S)-5,6,7,8-Tetrahydro-7,8-dihydroxy-2-[2-(3-phenoxyphenyl)ethyl]-6-(2-phenylethoxy)imidazo[1,2-a]pyridine-5-carboxylic acid Chemical Properties
Boiling point 741.1±60.0 °C(Predicted)
density 1.31±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted)
pka2.60±0.70(Predicted)
Safety Information
MSDS Information
(5S,6R,7R,8S)-5,6,7,8-Tetrahydro-7,8-dihydroxy-2-[2-(3-phenoxyphenyl)ethyl]-6-(2-phenylethoxy)imidazo[1,2-a]pyridine-5-carboxylic acid Usage And Synthesis
UsesHPSE1-IN-1 (compound 16) is a selective inhibitor of Heparanase-1 (HPSE1) with moderate inhibitory activity against exo-β-d-glucuronidase (GUSβ) and glucocerebrosidase (GBA)[1].
References[1] Imai Y et al. Discovery of a novel tetrahydroimidazo [1, 2-a] pyridine-5-carboxylic acid derivative as a potent and selective heparanase-1 inhibitor utilizing an improved synthetic approach[J]. Bioorganic & Medicinal Chemistry Letters, 2023: 129543.
(5S,6R,7R,8S)-5,6,7,8-Tetrahydro-7,8-dihydroxy-2-[2-(3-phenoxyphenyl)ethyl]-6-(2-phenylethoxy)imidazo[1,2-a]pyridine-5-carboxylic acid Preparation Products And Raw materials
Tag:(5S,6R,7R,8S)-5,6,7,8-Tetrahydro-7,8-dihydroxy-2-[2-(3-phenoxyphenyl)ethyl]-6-(2-phenylethoxy)imidazo[1,2-a]pyridine-5-carboxylic acid(2876926-29-1) Related Product Information
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