S-4-bromobenzylglutathione cyclopentyl diester
| 中文名称 | S-4-bromobenzylglutathione cyclopentyl diester |
|---|---|
| 中文同义词 | S-P-溴苄基谷胱甘肽环戊基二酯;化合物 T24598;N-[S-[(4-溴苯基)甲基]-N-L-G-谷氨酰基-L-半胱氨酰基]-甘氨酸二环戊酯;化合物 BRBZGCP2;N5-((R)-3-((4-溴苄基)硫基)-1-((2-(环戊氧基)-2-氧代乙基)氨基)-1-氧代丙-2-基)-L-谷氨酸环戊酯;S-对溴苄基谷胱甘肽环戊基二酯;S-对溴苄基谷胱甘肽环戊基二酯 |
| 英文名称 | S-4-bromobenzylglutathione cyclopentyl diester |
| 英文同义词 | S-4-bromobenzylglutathione cyclopentyl diester;S-p-Bromobenzylglutathione cyclopentyl diester;Glycine, N-[S-[(4-bromophenyl)methyl]-N-L-γ-glutamyl-L-cysteinyl]-, dicyclopentyl ester (9CI);S-p-Bromobenzylglutathione cyclopentyl diester >=98% (HPLC);BrBzGCp2;BBGC;BBGD;BrBzGCp2,BrBzGCp-2 |
| CAS号 | 166038-00-2 |
| 分子式 | C27H38BrN3O6S |
| 分子量 | 612.58 |
| EINECS号 | |
| 相关类别 | 制剂-抑制剂 |
| Mol文件 | 166038-00-2.mol |
| 结构式 |  |
S-4-bromobenzylglutathione cyclopentyl diester 性质
| 沸点 | 790.6±60.0 °C(Predicted) |
|---|---|
| 密度 | 1.38±0.1 g/cm3(Predicted) |
| 储存条件 | 2-8°C |
| 溶解度 | 二甲基亚砜：250 mg/mL（408.11 mM） |
| 形态 | 粉末 |
| 酸度系数(pKa) | 12.84±0.46(Predicted) |
| 颜色 | 白色至米色 |
BrBzGCp2 是乙二醛酶 1 (GLO1) 的抑制剂，其 GC50 为 4.23 μM (HL-60 细胞)。BrBzGCp2 具有抗肿瘤和神经保护活性。
GC50: 4.23 μM (GLO1).
GLO1 inhibition by BrBzGCp2 increases center time in the OF test, without changing distance traveled. GLO1 inhibition increases MG (methylglyoxal) concentration, thus reducing anxiety-like behavior.
BrBzGCp2 pre-treatment decreases seizure duration.
BrBzGCp2 injection alleviates the level of anxiety in mice, and mice with less anxiety and fear were more likely to explore the unknown area, implying that inhibition of GLO1 activity mitigated anxiety levels.
BrBzGCp2 treatment restores the VPA-induced inhibition effect on GABA
A
receptor activation.
BrBzGCp2 significantly lowers the blood pressure and ameliorated endothelial dysfunction in diabetic mice.
| Animal Model: | Male CD-1 mice. |
| Dosage: | 50 mg/kg. |
| Administration: | IP once (Two hours post-injection, mice were sacrificed, and brains were rapidly dissected and flash-frozen on dry ice. MG concentration was measured) |
| Result: | Allowed MG levels to accumulate for 2 hours |
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2025/05/22 | HY-136684 | S-4-bromobenzylglutathione cyclopentyl diester BrBzGCp2 | 166038-00-2 | 5mg | 800元 |
| 2025/05/22 | HY-136684 | S-4-bromobenzylglutathione cyclopentyl diester BrBzGCp2 | 166038-00-2 | 10mM * 1mLin DMSO | 1080元 |