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| | A 33853 Basic information |
| Product Name: | A 33853 | | Synonyms: | A 33853;2-[3-HYDROXY-2-[[(3-HYDROXY-2-PYRIDINYL)CARBONYL]AMINO]PHENYL]-4-BENZOXAZOLECARBOXYLIC ACID;Antibiotic A 33853;2-(3-Hydroxy-2-(3-hydroxypicolinamido)phenyl)-benzo[d]oxazole-4-carboxylic acid;2-[3-hydroxy-2-[(3-hydroxypyridine-2-carbonyl)-amino]-phenyl]-benzoxazole-4-carboxylic acid;4-Benzoxazolecarboxylic acid, 2-[3-hydroxy-2-[[(3-hydroxy-2-pyridinyl)carbonyl]amino]phenyl]- | | CAS: | 80148-45-4 | | MF: | C20H13N3O6 | | MW: | 391.33 | | EINECS: | | | Product Categories: | | | Mol File: | 80148-45-4.mol |  |
| | A 33853 Chemical Properties |
| Boiling point | 644.9±55.0 °C(Predicted) | | density | 1.588±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C | | pka | -2.81±0.30(Predicted) |
| | A 33853 Usage And Synthesis |
| Uses | Antibiotic A-338533, an antibiotic, can be isolated from Streptomyces strain. Antibiotic A-338533 has anti-bacterial activity against Staphylococcus aureus, Mycoplasma gallisepticum with MIC values of 2 μg/mL and ≤1.56 μg/mL, respectively[1]. | | in vivo | Antibiotic A-33853 (60 mg/kg; s.c.; single dose) is inactive against Mycoplasma gallisepticum in chicks in vivo[1].
Antibiotic A-33853 (70 mg/kg; s.c.; twice doses) is ineffective against S. aureus in mice in vivo[1].
Antibiotic A-33853 has an acute toxic dose with a LD50 value >300 mg/kg (i.p.) on mice model[1].
| | References | [1] In Pursuit of Natural Product Leads: Synthesis and Biological Evaluation of 2-[3-hydroxy-2-[(3-hydroxypyridine-2-carbonyl)amino]phenyl]benzoxazole-4-carboxylic acid (A-33853) and Its Analogues: Discovery of N-(2-Benzoxazol-2-ylphenyl)benzamides as Novel Antileishmanial Chemotypes
J. Med. Chem., 2008, 51 (23), pp 7344-7347
[2] Michel KH, et al. The discovery, fermentation, isolation, and structure of antibiotic A33853 and its tetraacetyl derivative. J Antibiot (Tokyo). 1984 May;37(5):441-5. DOI:10.7164/antibiotics.37.441 |
| | A 33853 Preparation Products And Raw materials |
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