- Thiotriazinone
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- $0.00 / 1Kg/Bag
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2025-08-25
- CAS:58909-39-0
- Min. Order: 1KG
- Purity: 98%min
- Supply Ability: 1000kg
- Thiotriazinone
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- $0.00 / 25KG
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2025-08-08
- CAS:58909-39-0
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 50000KG/month
- Thiotriazinone
-
- $10.00 / 1KG
-
2025-06-24
- CAS:58909-39-0
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 10 mt
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| | Thiotriazinone Basic information |
| Product Name: | Thiotriazinone | | Synonyms: | 2,5-Dihydro-6-hydroxy-3-mercapto-2-methyl-1,2,4-triazine-5-one;TTZ,TTA,OHMMT;Thiotriazinone(TTZ);3-MERCAPTO-2-METHYL-5-OXO-6-HYDROXY-1,2,4-TRIAZINE[TTZ,OHMMT];2,5-DIHYDRO-3-MERCAPTO-2-METHYL-5-OXO-6-HYDROXY-1,2,4-TRIAZINE;Thiotriazinone, 98+%;2,5-DIHYDRO-3-MERCAPTO-2-METHYL-5-OXO-6-HYDROXY-1,2,4-TRIAZINE/TTZ;THIOTRIAZINONE/2,5-DIHYDRO-6-HYDROXY-3-MERCAPTO-2-METHYL-5-OXO-1,2,4-TRIAZINE | | CAS: | 58909-39-0 | | MF: | C4H5N3O2S | | MW: | 159.17 | | EINECS: | 261-490-1 | | Product Categories: | Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Sulfur & Selenium Compounds;Building Blocks;Heterocyclic Building Blocks;Triazines | | Mol File: | 58909-39-0.mol |  |
| | Thiotriazinone Chemical Properties |
| Melting point | 168-171 °C (lit.) | | density | 1.62±0.1 g/cm3(Predicted) | | storage temp. | Sealed in dry,2-8°C | | solubility | DMSO (Sparingly), Methanol (Slightly) | | form | Solid | | pka | 5.34±0.20(Predicted) | | color | White to Off-White | | InChI | InChI=1S/C4H5N3O2S/c1-7-4(10)5-2(8)3(9)6-7/h1H3,(H,6,9)(H,5,8,10) | | InChIKey | UMWWHOXOVPIGFD-UHFFFAOYSA-N | | SMILES | N1C(=O)C(=O)NC(=S)N1C | | CAS DataBase Reference | 58909-39-0(CAS DataBase Reference) |
| Hazard Codes | Xi | | Risk Statements | 20/21/22-36 | | Safety Statements | 36-26 | | WGK Germany | 3 | | HS Code | 29336990 |
| | Thiotriazinone Usage And Synthesis |
| Chemical Properties | White Solid | | Uses | Reagent used in the preparation of Cefalosporins. | | Uses | Thiotriazinone can be used in the preparation of Cefalosporins. | | General Description | Tetrahydro-2-methyl-3-thioxo-1,2,4-triazine-5,6-dione is an intermediate for synthesizing ceftriaxone. | | Synthesis | General procedure for the synthesis of triazine ring from 2-methylaminothiourea and diethyl oxalate: 2-methylaminothiourea, mixed solvent (1:3 mass ratio of methanol to DMSO), diethyl oxalate and sodium methanolate were added to the reactor in the mass ratio 1:10:4:10. The cyclization reaction was carried out in the temperature range of 0-45°C. Upon completion of the reaction, acidification was carried out with hydrochloric acid in an amount of 30% by mass of 2-methylaminothiourea. Subsequently, the reaction mixture was filtered and dried to give the triazine ring in 91.6% yield. The purity of the product was assayed by HPLC and the by-product content was 0.0005% (5 ppm). The product was calculated as M (triazine ring) / [M (methylaminothiourea) * 159.17 / 105.16]. | | References | [1] Patent: CN104177305, 2017, B. Location in patent: Paragraph 0022; 0023; 0024; 0025; 0026; 0027; 0028-0031 |
| | Thiotriazinone Preparation Products And Raw materials |
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