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| | PTPσ Inhibitor, ISP Basic information |
| | PTPσ Inhibitor, ISP Chemical Properties |
| storage temp. | -20°C | | solubility | DMSO: 100mg/mL
water: 100mg/mL | | form | solid | | color | white |
| WGK Germany | WGK 1 | | Storage Class | 11 - Combustible Solids |
| | PTPσ Inhibitor, ISP Usage And Synthesis |
| Uses | A cell-permeable, TAT conjugated peptide derived from the protein tyrosine phosphatase sigma (PTPsigma) wedge domain that binds to PTPsigma and relieves glial-derived chondroitin sulfate proteoglycan (CSPG)-mediated inhibition. Shown to cross the blood-brain barrier. Does not bind to other CSPG receptors, such as LAR and NgRs. By blocking the PTPsigma-CSPG interaction it abolishes CSPG -mediated inhibition of axonal regrowth and sprouting. Shown to promote adult sensory neuron growth cone (~ 2.5 µM). Restores serotonergic innervations to the spinal cord below the level of injury and promotes progressive functional recovery of both locomotor and urinary systems after spinal cord injury in a rat model (11 µg/day).
Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water. | | Biological Activity | Cell permeable: yes', 'Primary Target
PTPδ', 'Reversible: yes |
| | PTPσ Inhibitor, ISP Preparation Products And Raw materials |
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