PI3Kγ inhibitor 7

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Company Name: TargetMol Chemicals Inc.
Tel: +17819995354
Email: marketing@targetmol.com
Products Intro: Product Name:PI3Kγ inhibitor 7
CAS:2575863-25-9
Package:25mg;1520USD|100mg;2500USD|50mg;1980USD
Company Name: Nantong Hanfang Biotechnology Co. , Ltd.  
Tel: hanfangpharma@126.com; 18616537568
Email: hanfangpharma@126.com
Products Intro: Product Name:PI3Kγ inhibitor 7
CAS:2575863-25-9
Purity:98%+ Package:1g；5g；10g；100g; 1kg
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Email: marketing@targetmol.cn
Products Intro: Product Name:PI3Kγ inhibitor 7
CAS:2575863-25-9
Package:1removed

PI3Kγ inhibitor 7 manufacturers

  • PI3Kγ inhibitor 7
  • PI3Kγ inhibitor 7 pictures
  • $1520.00 / 25mg
  • 2026-04-13
  • CAS:2575863-25-9
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  • Supply Ability: 10g
PI3Kγ inhibitor 7 Basic information
Product Name:PI3Kγ inhibitor 7
Synonyms:PI3Kγ inhibitor 7;Pyrazolo[1,5-a]pyrimidine-3-carboxamide, 2-amino-N-[(1S)-1-[5-[2-(1-cyclopropyl-1H-pyrazol-4-yl)ethynyl]-3,4-dihydro-4-oxo-3-phenyl-2-quinazolinyl]ethyl]-
CAS:2575863-25-9
MF:C31H25N9O2
MW:555.59
EINECS:
Product Categories:
Mol File:2575863-25-9.mol
PI3Kγ inhibitor 7 Structure
PI3Kγ inhibitor 7 Chemical Properties
density 1.472±0.14 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
pka9.822±0.46(predicted)
Safety Information
MSDS Information
PI3Kγ inhibitor 7 Usage And Synthesis
UsesPI3Kγ inhibitor 7 (compound 2) is a potent and orally active PI3Kγ inhibitor with IC50 values of 4768, 878.1, 3.42, 355.2 nM for PI3Kα, PI3Kβ, PI3Kγ, PI3Kδ, respectively. PI3Kγ inhibitor 7 shows antitumor activity[1]. PI3Kγ inhibitor 7 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
in vivo

PI3Kγ inhibitor 7 (compound 2) (5 mg/kg; p.o.) shows good pharmacokinetic absorption with t1/2 of 3.4 h, F of 60 % in ICR mice[1].
PI3Kγ inhibitor 7 (60 mg/kg; p.o.; daily for 21 days) shows antitumor activity in mice[1].

Animal Model:Female BALB/c mice (CT26 cells)[1]
Dosage:60 mg/kg
Administration:P.o.; daily for 21 days
Result:Decreased the tumor weight and with TGI of 51.2%, IR of 52.1%.
IC 50PI3Kα: 4768 nM (IC50); PI3Kβ: 878.1 nM (IC50); PI3Kγ: 3.42 nM (IC50); PI3Kδ: 355.2 nM (IC50)
References[1] HeJun Lv, et al. Alkyne derivative, preparation method for same, and uses thereof. WO2021004421A1.
PI3Kγ inhibitor 7 Preparation Products And Raw materials
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