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| | Insulin sensitizer C59 Basic information |
| | Insulin sensitizer C59 Chemical Properties |
| Boiling point | 491.664±45.00 °C(Press: 760.00 Torr)(predicted) | | density | 1.415±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | | storage temp. | 2-8°C | | solubility | DMSO: 2mg/mL, clear (Warmed) | | form | powder | | pka | 9.313±0.50(predicted) | | color | white to beige |
| WGK Germany | WGK 3 | | Storage Class | 11 - Combustible Solids |
| | Insulin sensitizer C59 Usage And Synthesis |
| Uses | GLUT4 activator 2 (C59) is an insulin sensitizer, which can be used for research of diabetic diseases. GLUT4 activator 2 improves glucose uptake and insulin sensitivity in rodents. GLUT4 activator 2 interacts with Unc119 and Unc119B resulting in increased insulin sensitivity and GLUT4 translocation[1]. | | Biological Activity | Orally available potentiator of insulin action th at significantly improves glucose tolerance in DIO mice; restores insulin-stimulated GLUT4 translocation.
| | References | [1] Yin TC, et al. Insulin sensitization by small molecules enhancing GLUT4 translocation. Cell Chem Biol. 2023 Aug 17;30(8):933-942.e6. DOI:10.1016/j.chembiol.2023.06.012 |
| | Insulin sensitizer C59 Preparation Products And Raw materials |
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