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| | Eg5-IN-2 Basic information |
| Product Name: | Eg5-IN-2 | | Synonyms: | Eg5-IN-2;1H-Imidazole-2-butanamide, 4-(2,5-difluorophenyl)-γ-[[[(3S,4R)-4-fluoro-3-pyrrolidinyl]methyl][(2S)-2-hydroxy-1-oxopropyl]amino]-N,β,β-trimethyl-1-(phenylmethyl)-, (γR)- | | CAS: | 1629735-05-2 | | MF: | C31H38F3N5O3 | | MW: | 585.66 | | EINECS: | | | Product Categories: | | | Mol File: | 1629735-05-2.mol |  |
| | Eg5-IN-2 Chemical Properties |
| Boiling point | 770.869±60.00 °C(Press: 760.00 Torr)(predicted) | | density | 1.288±0.14 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | | pka | 13.519±0.20(predicted) |
| | Eg5-IN-2 Usage And Synthesis |
| Uses | Eg5-IN-2 (Compound Scaffold B (4)) is an Eg5 inhibitor (IC50: < 0.5 nM). Eg5-IN-2 can be used as an ADC payload for synthesis of ADCs[1]. | | References | [1] Karpov AS, et al. Discovery of Potent and Selective Antibody-Drug Conjugates with Eg5 Inhibitors through Linker and Payload Optimization. ACS Med Chem Lett. 2019 Dec 3;10(12):1674-1679. DOI:10.1021/acsmedchemlett.9b00468 |
| | Eg5-IN-2 Preparation Products And Raw materials |
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