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| | LY117018 TFA Basic information |
| Product Name: | LY117018 TFA | | Synonyms: | LY117018 TFA;Methanone, [6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thien-3-yl][4-[2-(1-pyrrolidinyl)ethoxy]phenyl]-, 2,2,2-trifluoroacetate (1:1) | | CAS: | 2390041-98-0 | | MF: | C27H25NO4S.C2HF3O2 | | MW: | 573.58 | | EINECS: | | | Product Categories: | | | Mol File: | 2390041-98-0.mol |  |
| | LY117018 TFA Chemical Properties |
| form | Solid | | color | Light yellow to green yellow |
| | LY117018 TFA Usage And Synthesis |
| Uses | LY117018 TFA, a Raloxifene analog, is a selective estrogen receptor modulator. LY117018 TFA exerts antiproliferative effects on breast cancer cell lines[1][2][3]. | | References | [1] Dinda S, et al. Effects of LY117018 (a SERM analog of raloxifene) on tumor suppressor proteins and proliferation of breast cancer cells.Horm Mol Biol Clin Investig. 2010 Aug 1;2(1):211-7. DOI:10.1515/HMBCI.2010.021
[2] Baumann KH, et al. Effects of celecoxib and ly117018 combination on human breast cancer cells in vitro.Breast Cancer (Auckl). 2009 Apr 7;3:23-34. DOI:10.4137/bcbcr.s2291
[3] Yu J, et al.Raloxifene analogue LY117018 suppresses oxidative stress-induced endothelial cell apoptosis through activation of ERK1/2 signaling pathway.Eur J Pharmacol. 2008 Jul 28;589(1-3):32-6. DOI:10.1016/j.ejphar.2008.04.052 |
| | LY117018 TFA Preparation Products And Raw materials |
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