mDPR-Val-Cit-PAB-MMAE TFA

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mDPR-Val-Cit-PAB-MMAE TFA Suppliers list
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Email: marketing@targetmol.cn
Company Name: Zhejiang Huida Biotech Co., Ltd.  
Tel: 0571-89903022 18679456698
Email: zilong@hizyme.com
mDPR-Val-Cit-PAB-MMAE TFA Basic information
Product Name:mDPR-Val-Cit-PAB-MMAE TFA
Synonyms:mDPR-Val-Cit-PAB-MMAE TFA
CAS:2185872-76-6
MF:C65H100N12O15.C2HF3O2
MW:1403.59
EINECS:
Product Categories:
Mol File:2185872-76-6.mol
mDPR-Val-Cit-PAB-MMAE TFA Structure
mDPR-Val-Cit-PAB-MMAE TFA Chemical Properties
form Solid
color White to off-white
Safety Information
MSDS Information
mDPR-Val-Cit-PAB-MMAE TFA Usage And Synthesis
UsesmDPR-Val-Cit-PAB-MMAE TFA is a drug-linker conjugate for ADC (Drug-Linker Conjugates for ADC), consisting of a tubulin polymerization inhibitor MMAE (HY-15162) and an ADC linker (peptide Val-Cit- PAB) composition[1].
References[1] Moquist, et al. Preparation of drug conjugates of IgG1 antibodies with self-stabilizing linkers having improved physiochemical properties for treating cancers and autoimmune diseases. World Intellectual Property Organization, WO2018031690 A1. 2018-02-15.
mDPR-Val-Cit-PAB-MMAE TFA Preparation Products And Raw materials
Tag:mDPR-Val-Cit-PAB-MMAE TFA(2185872-76-6) Related Product Information
L-Valinamide, N-[[[4-[[N-[6-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-alanyl-L-alanyl-L-asparaginyl]amino]phenyl]methoxy]carbonyl]-N-methyl-L-valyl-N-[(1S,2R)-4-[(2S)-2-[(1R,2R)-3-[[(1R,2S)-2-hydroxy-1-methyl-2-phenylethyl]amino]-1-methoxy-2-methyl-3-oxopropyl]-1-pyrrolidinyl]-2-methoxy-1... Mal-PEG8-Val-Cit-PAB-MMAE L-Phenylalanine, N-methyl-N-[[[4-[[L-valyl-N5-(aminocarbonyl)-L-ornithyl]amino]phenyl]methoxy]carbonyl]-L-valyl-L-valyl-(3R,4S,5S)-3-methoxy-5-methyl-4-(methylamino)heptanoyl-(αR,βR,2S)-β-methoxy-α-methyl-2-pyrrolidinepropanoyl- [4-[[2-[[(2S)-2-[[2-[[2-[3-(2,5-dioxopyrrol-1-yl)propanoylamino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]acetyl]amino]phenyl]methyl N-[(2S)-1-[[(2S)-1-[[(3R,4S,5S)-1-[(2S)-2-[(1R,2R)-3-[[(1S,2R)-1-hydroxy-1-phenylpropan-2-yl]amino]-1-methoxy-2-methyl-3-oxopropyl]pyrrolidin-1-yl]-3-methoxy-5-methyl-1-oxoheptan-4-yl]-methylamino]-3-methyl-1-oxobutan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]-N-methylcarbamate mDPR-Val-Cit-PAB-MMAE MC-EVCit-PAB-MMAE