pan-KRAS-IN-5

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pan-KRAS-IN-5 Suppliers list
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Email: marketing@targetmol.cn
pan-KRAS-IN-5 Basic information
Product Name:pan-KRAS-IN-5
Synonyms:pan-KRAS-IN-5;Quinolinium, 2-[(1E)-2-[7-(diethylamino)-2-oxo-2H-1-benzopyran-3-yl]ethenyl]-6-fluoro-1-methyl-7-[[2-(1-pyrrolidinyl)ethyl]amino]-, iodide (1:1)
CAS:3027172-23-9
MF:C31H36FN4O2.I
MW:642.55
EINECS:
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Mol File:3027172-23-9.mol
pan-KRAS-IN-5 Structure
pan-KRAS-IN-5 Chemical Properties
form Solid
color Brown to black
Safety Information
MSDS Information
pan-KRAS-IN-5 Usage And Synthesis
Usespan-KRAS-IN-5 (compound 15a) is a pan-KRAS translation inhibitor by targeting 5′-UTR RNA G-quadruplexes (rG4s). pan-KRAS-IN-5 induces cell cycle arrest and promptes apoptosis in KRAS-driven cancer cells[1].
References[1] Mao-Lin Li, et al. Discovery of Novel Coumarin-quinolinium Derivatives as Pan-KRAS Translation Inhibitors by Targeting 5'-UTR RNA G-Quadruplexes. J Med Chem. 2024 Feb 8;67(3):1961-1981. DOI:10.1021/acs.jmedchem.3c01773
pan-KRAS-IN-5 Preparation Products And Raw materials
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