| Company Name: |
Invivochem |
| Tel: |
13829706226 |
| Email: |
191781430@QQ.com |
|
| | PDE11A4-IN-1 Basic information |
| Product Name: | PDE11A4-IN-1 | | Synonyms: | PDE11A4-IN-1;1H-Pyrazolo[3,4-b]pyridine-4-carboxamide, 3-(difluoromethyl)-N,N-diethyl-6-(1-methyl-1H-pyrazol-5-yl)-1-phenyl- | | CAS: | 3027607-92-4 | | MF: | C22H22F2N6O | | MW: | 424.45 | | EINECS: | | | Product Categories: | | | Mol File: | 3027607-92-4.mol |  |
| | PDE11A4-IN-1 Chemical Properties |
| Boiling point | 589.2±50.0 °C(predicted) | | density | 1.32±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted) | | pka | 0.92±0.10(predicted) |
| | PDE11A4-IN-1 Usage And Synthesis |
| Uses | PDE11A4-IN-1 (compound 23b) is a potent and selective PDE11A4 inhibitor with an IC50 of 12 nM. PDE11A4-IN-1 show high selectivity for PDE11A4 over PDE1, PDE2, PDE7, PDE8, and PDE9[1]. | | IC 50 | PDE11A4: 12 nM (IC50) | | References | [1] Shams Ul Mahmood, et al. First Optimization of Novel, Potent, Selective PDE11A4 Inhibitors for Age-Related Cognitive Decline. J Med Chem. 2023 Oct 20. DOI:10.1021/acs.jmedchem.3c01088 |
| | PDE11A4-IN-1 Preparation Products And Raw materials |
|