| Company Name: |
TargetMol |
| Tel: |
400-821-0310 15002144251 |
| Email: |
xuexiang.shao@tsbiochem.com |
|
| | SPOP-IN-2 Basic information |
| Product Name: | SPOP-IN-2 | | Synonyms: | SPOP-IN-2;5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[[5-(chloromethyl)-2-furanyl]carbonyl]amino]-3-ethenyl-8-oxo-, (6R,7R)- | | CAS: | 3031640-86-2 | | MF: | C15H13ClN2O5S | | MW: | 368.79 | | EINECS: | | | Product Categories: | | | Mol File: | 3031640-86-2.mol |  |
| | SPOP-IN-2 Chemical Properties |
| Boiling point | 710.6±60.0 °C(predicted) | | density | 1.58±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted) | | pka | 2.81±0.50(predicted) | | form | Solid | | color | Light yellow to yellow |
| | SPOP-IN-2 Usage And Synthesis |
| Uses | SPOP-IN-2 (compound E1) is a Speckle-type POZ protein (SPOP) inhibitor with IC50 of 0.58 μM, which disrupt the SPOP-subtrate interaction and selectively inhibits proliferation of ccRCC[1]. | | References | [1] Zhou C, et al., Synthesis and Biological Evaluation of β-Lactam Derivatives Targeting Speckle-Type POZ Protein (SPOP). ACS Med Chem Lett. 2024 Jan 25;15(2):270-279. DOI:10.1021/acsmedchemlett.3c00515 |
| | SPOP-IN-2 Preparation Products And Raw materials |
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