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| | STING agonist-23 Basic information |
| Product Name: | STING agonist-23 | | Synonyms: | STING agonist-23;3H-Imidazo[4,5-b]pyridine-6-carboxamide, 3-[(2E)-4-[5-(aminocarbonyl)-2-[[(1-ethyl-3-methyl-1H-pyrazol-5-yl)carbonyl]amino]-1H-benzimidazol-1-yl]-2-buten-1-yl]-2-[[(1-ethyl-3-methyl-1H-pyrazol-5-yl)carbonyl]amino]- | | CAS: | 2361570-16-1 | | MF: | C33H35N13O4 | | MW: | 677.72 | | EINECS: | | | Product Categories: | | | Mol File: | 2361570-16-1.mol |  |
| | STING agonist-23 Chemical Properties |
| density | 1.518±0.14 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | | pka | 9.616±0.50(predicted) | | form | Solid | | color | White to light yellow |
| | STING agonist-23 Usage And Synthesis |
| Uses | STING agonist-23 (CF502) is a non-nucleotide small-molecule STING agonist. STING agonist-23 activates STING, increases phosphorylation of STING, TBK1 and IRF3. STING agonist-23 promotes the levels of IFN-β, IL-6, CXCL-10, TNF-α, ISG-15, and CCL-5 in tumor cells. STING agonist-23 exhibits activity against SARS-CoV series strains[1]. | | in vivo | STING agonist-23 adjuvant (20μg STING agonist-23 and 5 μg RBD-Fc per mouse; im; 3 times at 14-day intervals) induces strong antibody immune response induced by the SARS-CoV-2 RBD-Fc protein in mice model[1]. | | References | [1] Liu Z, et al. A novel STING agonist-adjuvanted pan-sarbecovirus vaccine elicits potent and durable neutralizing antibody and T cell responses in mice, rabbits and NHPs. Cell Res. 2022 Mar;32(3):269-287. DOI:10.1038/s41422-022-00612-2 |
| | STING agonist-23 Preparation Products And Raw materials |
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