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| | Thalidomide-PEG2-NH2 hydrochloride Basic information |
| Product Name: | Thalidomide-PEG2-NH2 hydrochloride | | Synonyms: | Thalidomide-PEG2-NH2 hydrochloride;1H-Isoindole-1,3(2H)-dione, 4-[2-(2-aminoethoxy)ethoxy]-2-(2,6-dioxo-3-piperidinyl)-, hydrochloride (1:1);4-(H2N-PEG2)-Thalidomide HCl | | CAS: | 2891597-17-2 | | MF: | C17H19N3O6.ClH | | MW: | 397.81 | | EINECS: | | | Product Categories: | | | Mol File: | 2891597-17-2.mol |  |
| | Thalidomide-PEG2-NH2 hydrochloride Chemical Properties |
| form | Solid | | color | White to off-white |
| | Thalidomide-PEG2-NH2 hydrochloride Usage And Synthesis |
| Uses | Thalidomide-PEG2-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate (E3 Ligase Ligand-Linker Conjugates) that incorporates the Thalidomide (Thalidomide (HY-14658)) based cereblon ligand and a linker used in PROTAC technology[1]. | | IC 50 | Cereblon | | References | [1] Sato T, et al. Cereblon-Based Small-Molecule Compounds to Control Neural Stem Cell Proliferation in Regenerative Medicine. Front Cell Dev Biol. 2021;9:629326. Published 2021 Mar 11. DOI:10.3389/fcell.2021.629326
[2] Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-996. DOI:10.1016/j.ccell.2020.07.008 |
| | Thalidomide-PEG2-NH2 hydrochloride Preparation Products And Raw materials |
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