Benzamide, 2-fluoro-N-[(1R)-1-methyl-2-[methyl(phenylmethyl)amino]ethyl]-4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]-

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Benzamide, 2-fluoro-N-[(1R)-1-methyl-2-[methyl(phenylmethyl)amino]ethyl]-4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]- Suppliers list
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Email: marketing@targetmol.cn
Products Intro: Product Name:NT376
CAS:2820208-97-5
Package:50mg;10mg
Benzamide, 2-fluoro-N-[(1R)-1-methyl-2-[methyl(phenylmethyl)amino]ethyl]-4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]- Basic information
Product Name:Benzamide, 2-fluoro-N-[(1R)-1-methyl-2-[methyl(phenylmethyl)amino]ethyl]-4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]-
Synonyms:Benzamide, 2-fluoro-N-[(1R)-1-methyl-2-[methyl(phenylmethyl)amino]ethyl]-4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]-;NT376
CAS:2820208-97-5
MF:C21H20F4N4O2
MW:436.4
EINECS:
Product Categories:
Mol File:2820208-97-5.mol
Benzamide, 2-fluoro-N-[(1R)-1-methyl-2-[methyl(phenylmethyl)amino]ethyl]-4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]- Structure
Benzamide, 2-fluoro-N-[(1R)-1-methyl-2-[methyl(phenylmethyl)amino]ethyl]-4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]- Chemical Properties
density 1.297±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)
pka12.89±0.46(predicted)
Safety Information
MSDS Information
Benzamide, 2-fluoro-N-[(1R)-1-methyl-2-[methyl(phenylmethyl)amino]ethyl]-4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]- Usage And Synthesis
UsesNT376 is a high potency and selectivity inhibitor of class-IIa Histone deacetylases (HDAC) with an IC50 value of 32 nM, similar to NT160 (HY-149285) (IC50= 46 nM) in HT-29 cells. NT376 is proming for research of various cancers and in the diseases of the central nervous system (CNS) such as Alzheimer’s and Huntington’s diseases[1].
IC 50HDAC4: 1.26 nM (IC50, HT-29 cells); HDAC5: 2.85 nM (IC50, HT-29 cells); HDAC1: 1483 nM (IC50, HT-29 cells); HDAC11: 4851 nM (IC50, HT-29 cells); Class I/IIb: >4000 nM (IC50, HT-29 cells); HDAC6: 5035 nM (IC50, HT-29 cells)
References[1] Xu S, et al. Design and radiosynthesis of class-IIa HDAC inhibitor with high molar activity via repositioning the 18F-radiolabel[J]. Sci Rep. 2024 Jul 2;14(1):15100. DOI:10.1038/s41598-024-65668-z
Benzamide, 2-fluoro-N-[(1R)-1-methyl-2-[methyl(phenylmethyl)amino]ethyl]-4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]- Preparation Products And Raw materials
Tag:Benzamide, 2-fluoro-N-[(1R)-1-methyl-2-[methyl(phenylmethyl)amino]ethyl]-4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]-(2820208-97-5) Related Product Information