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| | Tyrosinase (206-214) (human) Basic information |
| Product Name: | Tyrosinase (206-214) (human) | | Synonyms: | (2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-2-aminopropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]pyrrolidine-2-carbonyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-4-methylpentanoyl]amino]-3-phenylpropanoic acid;L-Phenylalanine, L-alanyl-L-phenylalanyl-L-leucyl-L-prolyl-L-tryptophyl-L-histidyl-L-arginyl-L-leucyl-;L-Alanyl-L-phenylalanyl-L-leucyl-L-prolyl-L-tryptophyl-L-histidyl-L-arginyl-L-leucyl-L-phenylalanine | | CAS: | 166188-11-0 | | MF: | C61H83N15O10 | | MW: | 1186.41 | | EINECS: | | | Product Categories: | | | Mol File: | 166188-11-0.mol |  |
| | Tyrosinase (206-214) (human) Chemical Properties |
| density | 1.38±0.1 g/cm3(Predicted) | | pka | 3.50±0.10(Predicted) | | form | Solid | | color | White to off-white |
| | Tyrosinase (206-214) (human) Usage And Synthesis |
| Uses | Tyrosinase (206-214), human (AFLPWHRLF), a 9-amino acid peptide, is a tyrosinase epitope. Tyrosinase (206-214), human can be recognized by HLA-A24 restricted, tumor-infiltrating lymphocytes (TIL)[1]. | | in vivo | Tyrosinase (206-214) is administered intranasally (i.n.; 45 μL; weekly for three weeks) into HLA-A24 transgenic (A24Tg) mice. Tyrosinase (206-214) shows an accumulation of murine CD3+ and CD8+ cells around the bronchioles. All A24Tg immunized with Tyrosinase (206-214) died after lethal A/HK483 infection[2]. | | References | [1] X Kang, et al. Identification of a tyrosinase epitope recognized by HLA-A24-restricted, tumor-infiltrating lymphocytes. J Immunol. 1995 Aug 1;155(3):1343-8. PMID:7543520
[2] Toru Ichihashi, et al. Cross-protective peptide vaccine against influenza A viruses developed in HLA-A*2402 human immunity model. PLoS One. 2011;6(9):e24626. DOI:10.1371/journal.pone.0024626 |
| | Tyrosinase (206-214) (human) Preparation Products And Raw materials |
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